ERO1LB Antibody (M37-P5D11) [Janelia Fluor® 635]

Product Discontinued

ERO1LB Antibody (M37-P5D11) [Janelia Fluor® 635] Summary

• Immunogen: Peptide - LAPSRGEDDG
• Isotype: IgG1 Kappa
• Clonality: Monoclonal
• Host: Mouse
• Gene: ERO1B
• Purity: Protein A purified

Applications/Dilutions

• Dilutions:
  • ELISA
  • Immunohistochemistry
  • Immunohistochemistry-Paraffin
  • Western Blot
• Application Notes: Optimal dilution of this antibody should be experimentally determined.

Packaging, Storage & Formulations

• Storage: Store at 4C in the dark.
• Buffer: 50mM Sodium Borate
• Preservative: 0.05% Sodium Azide
• Purity: Protein A purified

Notes

Sold under license from the Howard Hughes Medical Institute, Janelia Research Campus.

Alternate Names for ERO1LB Antibody (M37-P5D11) [Janelia Fluor® 635]

• DKFZp779C1042
• DKFZp779I0141
• EC 1.8.4
• EC 1.8.4.-
• Endoplasmic oxidoreductin-1-like protein B
• ERO1-L(beta)
• ERO1-L-beta
• ERO1-like beta (S. cerevisiae)
• ERO1-like protein beta
• FLJ11003
• oxidoreductin-1-L-beta

Background

Essential oxidoreductase that oxidizes proteins in the endoplasmic reticulum to produce disulfide bonds. Acts by oxidizing directly P4HB/PDI isomerase through a direct disulfide exchange. Does not act as a direct oxidant of folding substrate, but relies on P4HB/PDI to transfer oxidizing equivalent. Associates with ERP44 but not with GRP54, demonstrating that it does not oxidize all PDI related proteins and can discriminate between PDI and related proteins. Its reoxidation probably involves electron transfer to molecular oxygen via FAD. Acts independently of glutathione. May be responsible for a significant proportion of reactive oxygen species (ROS) in the being a source of oxidative stress. Required for the folding of cell, thereby being a source of oxidative stress

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: ERO1B