ERO1LB Products

Description

Essential oxidoreductase that oxidizes proteins in the endoplasmic reticulum to produce disulfide bonds. Acts by oxidizing directly P4HB/PDI isomerase through a direct disulfide exchange. Does not act as a direct oxidant of folding substrate, but relies on P4HB/PDI to transfer oxidizing equivalent. Associates with ERP44 but not with GRP54, demonstrating that it does not oxidize all PDI related proteins and can discriminate between PDI and related proteins. Its reoxidation probably involves electron transfer to molecular oxygen via FAD. Acts independently of glutathione. May be responsible for a significant proportion of reactive oxygen species (ROS) in the being a source of oxidative stress. Required for the folding of cell, thereby being a source of oxidative stress

Bioinformatics

Product By Gene ID	56605
Alternate Names	DKFZp779C1042 DKFZp779I0141 EC 1.8.4 EC 1.8.4.- Endoplasmic oxidoreductin-1-like protein B ERO1-L(beta) ERO1-L-beta ERO1-like beta (S. cerevisiae) ERO1-like protein beta FLJ11003 oxidoreductin-1-L-beta

Research Areas for ERO1LB

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Signal Transduction