EPCR Antibody

Western Blot: EPCR Antibody [H00010544-D01P] - Analysis of PROCR expression in transfected 293T cell line by PROCR polyclonal antibody.Lane 1: PROCR transfected lysate(26.70 KDa).Lane 2: Non-transfected lysate.

Product Discontinued

EPCR Antibody Summary

• Immunogen: PROCR (NP_006395.2, 1 a.a. - 238 a.a.) full-length human protein. MLTTLLPILLLSGWAFCSQDASDGLQRLHMLQISYFRDPYHVWYQGNASLGGHLTHVLEGPDTNTTIIQLQPLQEPESWARTQSGLQSYLLQFHGLVRLVHQERTLAFPLTIRCFLGCELPPEGSRAHVFFEVAVNGSSFVSFRPERALWQADTQVTSGVVTFTLQQLNAYNRTRYELREFLEDTCVQYVQKHISAENTKGSQTSRSYTSLVLGVLVGSFIIAGVAVGIFLCTGGRRC
• Specificity: PROCR - protein C receptor, endothelial (EPCR),
• Isotype: IgG
• Clonality: Polyclonal
• Host: Rabbit
• Gene: PROCR
• Purity: Protein A purified

Applications/Dilutions

• Dilutions:
  • Western Blot 1:500
• Application Notes: Antibody reactive against Recombinant Protein with GST tag on ELISA and Western Blot and also on transfected lysate in western blot. GST tag alone is used as a negative control.

Reactivity Notes

Use in Mouse reported in scientific literature (PMID:35320720).

Packaging, Storage & Formulations

• Storage: Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.
• Buffer: PBS (pH 7.4)
• Preservative: No Preservative
• Purity: Protein A purified

Notes

This product is produced by and distributed for Abnova, a company based in Taiwan.

Alternate Names for EPCR Antibody

• APC receptor
• CCCA
• CCD41
• CCD41centrosome-associated protein
• CD201 antigen
• CD201
• centrocyclin
• Endothelial cell protein C receptor
• endothelial protein C receptor
• EPCR
• EPCRMGC23024
• PROCR
• protein C receptor, endothelial

Background

The protein encoded by this gene is a receptor for activated protein C, a serine protease activated by and involved in the blood coagulation pathway. The encoded protein is an N-glycosylated type I membrane protein that enhances the activation of protein C. Mutations in this gene have been associated with venous thromboembolism and myocardial infarction, as well as with late fetal loss during pregnancy. [provided by RefSeq]

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Publications for EPCR Antibody (H00010544-D01P)(3)

Publications using H00010544-D01P

• Liu C, Lin C, Wang D et al. Procr functions as a signaling receptor and is essential for the maintenance and self-renewal of mammary stem cells Cell reports 2022-03-22 [PMID: 35320720] (WB, Mouse)
• Wang D, Hu X, Liu C et al. Protein C receptor is a therapeutic stem cell target in a distinct group of breast cancers Cell Res. [PMID: 31481760] (WB)
• Ku SK, Kim JA, Bae JS et al. Piperlonguminine Downregulates Endothelial Protein C Receptor Shedding In Vitro and In Vivo. Inflammation 2013-10-15 [PMID: 24127121]

Bioinformatics

• Gene Symbol: PROCR
• Entrez:
  • 10544(Human)
• Uniprot:
  • NP_006395.2()