EPCR Antibody (304519) [Alexa Fluor® 750]

• Reactivity: Hu
• Applications: WB, IHC
• Clone: 304519
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: Alexa Fluor 750

EPCR Antibody (304519) [Alexa Fluor® 750] Summary

• Immunogen: Mouse myeloma cell line NS0-derived recombinant human EPCR
  Ser18-Ser210
  Accession # Q9UNN8
• Specificity: Detects human EPCR in direct ELISAs and Western blots. In direct ELISAs and Western blots, no cross‑reactivity with recombinant mouse EPCR is observed.
• Isotype: IgG2b
• Clonality: Monoclonal
• Host: Mouse
• Purity Statement: Protein A or G purified

Applications/Dilutions

• Dilutions:
  • Immunohistochemistry
  • Western Blot

Packaging, Storage & Formulations

• Storage: Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied
• Buffer: Supplied 0.2mg/ml in 1X PBS with RDF1 and 0.09% Sodium Azide

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for EPCR Antibody (304519) [Alexa Fluor® 750]

• APC receptor
• CCCA
• CCD41
• CCD41centrosome-associated protein
• CD201 antigen
• CD201
• centrocyclin
• Endothelial cell protein C receptor
• endothelial protein C receptor
• EPCR
• EPCRMGC23024
• PROCR
• protein C receptor, endothelial

Background

Protein C is a vitamin K-dependent serine protease that plays a major role in blood coagulation. Binding of Protein C to EPCR (endothelial protein C receptor) leads to the proteolytic activation of PAR1 (protease-activated receptor 1) on endothelial cells and subsequent up-regulation of Protein C-induced genes. EPCR is a type I transmembrane glycoprotein in the CD1/MHC family. It is expressed most strongly in the endothelial cells of arteries and veins in heart and lung. Membrane bound EPCR is released by metalloproteolytic cleavage to generate the soluble receptor. The extracellular domain of human and mouse EPCR shares approximately 61% amino acid sequence homology.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.