EMR1 Antibody

Product Discontinued

EMR1 Antibody Summary

• Immunogen: Synthetic peptide derived from N-terminus of mouse F4/80 protein.
• Localization: Membrane
• Isotype: IgG
• Clonality: Polyclonal
• Host: Rabbit
• Gene: ADGRE1
• Purity: Immunogen affinity purified

Applications/Dilutions

• Dilutions:
  • Immunohistochemistry 1:100
  • Immunohistochemistry-Paraffin 1:100
• Theoretical MW: 160 kDa.
  Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Reactivity Notes

Tested in Human. Based on sequence identity cross reactivity is expected with Mouse and Rat.

Packaging, Storage & Formulations

• Storage: Store at 4C. Do not freeze.
• Buffer: PBS (pH 7.6) and 1.0% BSA
• Preservative: 0.1% Sodium Azide
• Purity: Immunogen affinity purified

Alternate Names for EMR1 Antibody

• ADGRE1
• egf-like module containing, mucin-like, hormone receptor-like 1
• egf-like module containing, mucin-like, hormone receptor-like sequence 1
• EGF-like module receptor 1
• EGF-like module-containing mucin-like hormone receptor-like 1
• EMR1 hormone receptor
• EMR1
• TM7LN3

Background

F4/80 antigen is a 160 kDa cell surface glycoprotein that is a member of the EGF TM7 family of proteins which shares 68% overall amino acid identity with human EGF module containing mucin like hormone receptor 1 (EMR1). Expression of F4/80 is heterogeneous and is reported to vary during macrophage maturation and activation. The F4/80 antigen is expressed on a wide range of mature tissue macrophages including Kupffer cells, Langerhans, microglia, macrophages located in the gut lamina propria, peritoneal cavity, lung, thymus, bone marrow stroma and macrophages in the red pulp of the spleen. F4/80 expression has also been reported on a subpopulation of dendritic cells but is absent from macrophages located in T cell areas of the spleen and lymph node. The ligands and biological functions of the F4/80 antigen have not yet been determined but recent studies suggest a role for F4/80 in the generation of efferent CD8+ve regulatory T cells.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

FAQs for EMR1 Antibody (NBP2-21761). (Showing 1 - 1 of 1 FAQ).

1. What is the immunogen sequence of this F4/80/EMR1 antibodies antibody?
   • A synthetic sequence within the N-terminal region of mouse F4/80 protein. The exact sequence is proprietary.

Bioinformatics

• Gene Symbol: ADGRE1
• Entrez:
  • 13733(Mouse)