DYRK1A Antibody - BSA Free

Western Blot: DYRK1A Antibody [NBP1-76559] - Western blot analysis of DYRK1A expression in K562 cell lysate with DYRK1A antibody at (A) 1 and (B) 2 ug/ml.

Western Blot: DYRK1A Antibody [NBP1-76559] - Analysis of DYRK1A in HeLa cell lysate with DYRK1A antibody at (A) 1 and (B) 2 ug/mL.

Immunocytochemistry/ Immunofluorescence: DYRK1A Antibody - BSA Free [NBP1-76559] - Immunocytochemistry of DYRK1A in HeLa cells with DYRK1A antibody at 10 ug/mL.

• Reactivity: Hu, Mu, Rt
• Applications: WB, ELISA, ICC/IF
• Clonality: Polyclonal
• Host: Rabbit
• Conjugate: Unconjugated
• Format: BSA Free
• Concentration: 1 mg/ml

DYRK1A Antibody - BSA Free Summary

• Description: Novus Biologicals Rabbit DYRK1A Antibody - BSA Free (NBP1-76559) is a polyclonal antibody validated for use in WB, ELISA and ICC/IF. All Novus Biologicals antibodies are covered by our 100% guarantee.
• Immunogen: Antibody was raised against a 17 amino acid synthetic peptide near the carboxy terminus of human DYRK1A. The immunogen is located within the last 50 amino acids of DYRK1A. Amino Acid Squence: LTMRQGADREESPMTGV
• Specificity: Multiple isoforms of DYRK1A are known to exist. DYRK1A antibody will not cross-react with other DYRK family members
• Isotype: IgG
• Clonality: Polyclonal
• Host: Rabbit
• Gene: DYRK1A
• Purity: Peptide affinity purified

Applications/Dilutions

• Dilutions:
  • ELISA 1:100-1:2000
  • Immunocytochemistry/ Immunofluorescence 10 ug/mL
  • Western Blot 1-2 ug/ml
• Theoretical MW: 90 kDa.
  Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.
• Control Peptide:

  DYRK1A Peptide (NBP1-76559PEP)

Packaging, Storage & Formulations

• Storage: Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
• Buffer: PBS
• Preservative: 0.02% Sodium Azide
• Concentration: 1 mg/ml
• Purity: Peptide affinity purified

Alternate Names for DYRK1A Antibody - BSA Free

• dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A
• DYRK1
• DYRK1A
• MNBEC 2.7.110EC 2.7.12
• MNBH

Background

DYRK1A is a member of the dual-specificity tyrosine phosphorylation-regulated kinase (DYRK) family and is thought to be involved in neuronal differentiation, neurodegenerative diseases, and is considered to be a strong candidate gene for learning defects associated with Down syndrome. DYRK1A phosphorylates several transcription factors such as p53, leading to inhibition of embryonic neuronal cell proliferation. DYRK1A associates with multiple proteins, including SPRED1 and SPRED2; this association appears to inhibit the phosphorylation activity of DYRK1A. Recent evidence also suggests that DYRK1A may be involved in the replication of HIV-1.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: DYRK1A
• Uniprot:
  • NP_001387(Human)