DYRK1A Products

Description

DYRK1A encodes a member of the Dual-specificity tyrosine phosphorylation-regulated kinase (DYRK) family. This member contains a nuclear targeting signal sequence, a protein kinase domain, a leucine zipper motif, and a highly conservative 13-consecutive-histidine repeat. It catalyzes its autophosphorylation on serine/threonine and tyrosine residues. It may play a significant role in a signaling pathway regulating cell proliferation and may be involved in brain development. This gene is a homolog of Drosophila mnb (minibrain) gene and rat Dyrk gene. It is localized in the Down syndrome critical region of chromosome 21, and is considered to be a strong candidate gene for learning defects associated with Down syndrome. Alternative splicing of this gene generates several transcript variants differing from each other either in the 5' UTR or in the 3' coding region. These variants encode at least five different isoforms.

Bioinformatics

Entrez	13548 Mouse 1859 Human 25255 Rat
Uniprot	DYRA_HUMAN Human NP_001387 Human NP_569120 Human Q13627 Human
Product By Gene ID	1859
Alternate Names	dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A DYRK1 MNBEC 2.7.110EC 2.7.12

Research Areas for DYRK1A

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Protein Kinase