DR6/TNFRSF21 Antibody

Western Blot: DR6 Antibody [NB600-1400] - Western blot analysis of 30 ug of total cell lysate from Jurkat (lane 1), HeLa (lane 2), and Daudi (lane 3) cells with NB600-1400 at 2 ug/ml.

Product Discontinued

DR6/TNFRSF21 Antibody Summary

• Immunogen: The antibody was raised against the cytoplasmic domain (amino acids 371-655) of human DR6 protein.
• Localization: Cell Membrane
• Isotype: IgG
• Clonality: Polyclonal
• Host: Rabbit
• Gene: TNFRSF21
• Purity: Protein G purified

Applications/Dilutions

• Dilutions:
  • Western Blot 2 - 4 ug/ml
• Application Notes: Western Blot: Detects a band of approximately 66 kDa (predicted molecular weight: 79 kDa).
• Control:

  DR6/TNFRSF21 Overexpression Lysate

Reactivity Notes

Cross-reacts with Human.

Packaging, Storage & Formulations

• Storage: Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
• Buffer: PBS containing 0.05% BSA
• Preservative: 0.05% Sodium Azide
• Concentration: 0.5 mg/ml
• Purity: Protein G purified

Alternate Names for DR6/TNFRSF21 Antibody

• BM-018
• CD358 antigen
• CD358
• Death receptor 6
• DR6
• DR6TNFR-related death receptor 6
• MGC31965
• TNFRSF21
• tumor necrosis factor receptor superfamily member 21
• tumor necrosis factor receptor superfamily, member 21

Background

Apoptosis, or programmed cell death, occurs during normal cellular differentiation and development of multicellular organisms. Apoptosis is induced by certain cytokines including TNF and Fas ligand in the TNF family through their death domain containing receptors, TNFR1 and Fas. A novel death domain containing receptor was recently identified and designated DR6 (for death receptor 6) (1). The extracellular domain of DR6 contains four TNFR-like cysteine rich motifs that are related to those of osteoprotegerin (OPG) (2) and TNFR2 (3) with 36% and 42% amino acid identities, respectively. The death domain of DR6 (amino acids 428-494) located adjacent to the transmembrane domain is most related to TNFR1 (27.2%) and least to DR5 (19.7%) (1).

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

FAQs for DR6/TNFRSF21 Antibody (NB600-1400). (Showing 1 - 1 of 1 FAQ).

1. We have a stock set to expire soon. Would you be able to recommend a date extension for this lot?
   • The antibody is warrantied for 1 year after receipt. However, purified non-conjugated antibodies like this one are in general are very stable when stored correctly and freeze-thaw cycles are avoided. Antibodies can be stable for many years. It would be hard though to know exactly at which date beyond the original warranty any given antibody would no longer perform.

Bioinformatics

• Gene Symbol: TNFRSF21
• Entrez:
  • 27242(Human)
• Uniprot:
  • NP_043000(Virus)