DR6/TNFRSF21 Products

Description

Apoptosis is induced by certain cytokines including TNF and Fas ligand of the TNF family through their death domain containing receptors, TNFR1 and Fas. Several novel death receptors including DR3, DR4, and DR5 were recently identified. A new death domain containing receptor in the TNFR family was cloned recently and termed DR6 for death receptor 6. Like TNFR1, DR6 interacts with death domain containing adapter molecule TRADD. Overexpression of DR6 induces apoptosis and activates NF-kB and JNK. DR6 is widely expressed inhuman tissues and cell lines. The ligand for DR6 hasnot been identified.

Bioinformatics

Entrez	27242 Human
Uniprot	AAH05192 Human AAH05192.1 Human AAH10241 Human AF068868 Human NM_014452 Human NP_055267 Human NP_055267.1 Human O75509 Human
Product By Gene ID	27242
Alternate Names	BM-018 CD358 antigen Death receptor 6 DR6TNFR-related death receptor 6 MGC31965 tumor necrosis factor receptor superfamily member 21 tumor necrosis factor receptor superfamily, member 21

Research Areas for DR6/TNFRSF21

Find related products by research area and learn more about each of the different research areas below.

Apoptosis
Cell Biology