DR6/TNFRSF21 Antibody (DR-6-04-EC) [DyLight 488]

Product Discontinued

DR6/TNFRSF21 Antibody (DR-6-04-EC) [DyLight 488] Summary

• Immunogen: A fusion protein representing amino acids 42-335 (extracellular part) of human DR6 linked to the Fc portion of human IgG1 was used as an immunogen.
• Localization: Cell Membrane
• Specificity: The antibody DR-6-04-EC recognizes human DR6 (Death receptor-6), a type I transmembrane protein containing cytoplasmic death domain, widely expressed in most human tissues and cell lines.
• Isotype: IgG1
• Clonality: Monoclonal
• Host: Mouse
• Gene: TNFRSF21
• Purity: Protein A purified

Applications/Dilutions

• Dilutions:
  • Flow Cytometry
  • Immunocytochemistry/ Immunofluorescence

Packaging, Storage & Formulations

• Storage: Store at 4C in the dark.
• Buffer: 50mM Sodium Borate
• Preservative: 0.05% Sodium Azide
• Purity: Protein A purified

Notes

Dylight (R) is a trademark of Thermo Fisher Scientific Inc. and its subsidiaries. This conjugate is made on demand. Actual recovery may vary from the stated volume of this product. The volume will be greater than or equal to the unit size stated on the datasheet.

Alternate Names for DR6/TNFRSF21 Antibody (DR-6-04-EC) [DyLight 488]

• BM-018
• CD358 antigen
• CD358
• Death receptor 6
• DR6
• DR6TNFR-related death receptor 6
• MGC31965
• TNFRSF21
• tumor necrosis factor receptor superfamily member 21
• tumor necrosis factor receptor superfamily, member 21

Background

Apoptosis is induced by certain cytokines including TNF and Fas ligand of the TNF family through their death domain containing receptors, TNFR1 and Fas. Several novel death receptors including DR3, DR4, and DR5 were recently identified. A new death domain containing receptor in the TNFR family was cloned recently and termed DR6 for death receptor 6. Like TNFR1, DR6 interacts with death domain containing adapter molecule TRADD. Overexpression of DR6 induces apoptosis and activates NF-kB and JNK. DR6 is widely expressed inhuman tissues and cell lines. The ligand for DR6 hasnot been identified.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: TNFRSF21