Home » DR6/TNFRSF21 » DR6/TNFRSF21 Antibodies » DR6/TNFRSF21 Antibody (DR-6-04-EC)

DR6/TNFRSF21 Antibody (DR-6-04-EC)

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Product Details

Summary
Product Discontinued
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Order Details


    • Catalog Number
      NB500-345
    • Availability
      Product Discontinued

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DR6/TNFRSF21 Antibody (DR-6-04-EC) Summary

Immunogen
A fusion protein representing amino acids 42-335 (extracellular part) of human DR6 linked to the Fc portion of human IgG1 was used as an immunogen.
Localization
Cell Membrane
Specificity
The antibody DR-6-04-EC recognizes human DR6 (Death receptor-6), a type I transmembrane protein containing cytoplasmic death domain, widely expressed in most human tissues and cell lines.
Isotype
IgG1
Clonality
Monoclonal
Host
Mouse
Gene
TNFRSF21
Purity
Protein A purified
Innovator's Reward
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Applications/Dilutions

Dilutions
  • CyTOF-ready
  • Flow Cytometry 1 ug/ml
  • Immunocytochemistry/ Immunofluorescence 1:10-1:2000
  • Immunoprecipitation 1:50
Application Notes
Antibody immunoprecipitates overexpressed DR6 from DR6-transfected HEK/293 cells. This antibody is CyTOF ready.
Control
DR6/TNFRSF21 Overexpression Lysate

Packaging, Storage & Formulations

Storage
Store at 4C. Do not freeze.
Buffer
PBS (pH 7.4)
Preservative
0.09% Sodium Azide
Concentration
1.0 mg/ml
Purity
Protein A purified

Alternate Names for DR6/TNFRSF21 Antibody (DR-6-04-EC)

  • BM-018
  • CD358 antigen
  • CD358
  • Death receptor 6
  • DR6
  • DR6TNFR-related death receptor 6
  • MGC31965
  • TNFRSF21
  • tumor necrosis factor receptor superfamily member 21
  • tumor necrosis factor receptor superfamily, member 21

Background

CD358 / DR6 (Death Receptor-6) is a type I transmembrane protein of the TNF receptor superfamily, expressed in most human tissues and able of inducing apoptosis through its cytoplasmic death domain. Unlike TNFR1 and Fas, DR6 induces apoptosis independently of FADD adaptor. In immune system, DR6 serves as an important regulator for CD4+ T cell proliferation and Th differentiation, and provides also a regulatory mechanism for B cell activation and humoral immune responses

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Video Protocols

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Control Lysate(s)

DR6/TNFRSF21 Overexpression Lysate

Secondary Antibodies

 

Isotype Controls

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Bioinformatics

Gene Symbol TNFRSF21
Entrez