DPPII/QPP/DPP7 Antibody (398024)

• Reactivity: Hu
• Applications: WB
• Clone: 398024
• Clonality: Monoclonal
• Host: Rat
• Conjugate: Unconjugated
• Concentration: LYOPH

DPPII/QPP/DPP7 Antibody (398024) Summary

• Immunogen: Mouse myeloma cell line NS0-derived recombinant human DPPII/QPP/DPP7
  Gly22-Leu492
  Accession # AAH11907
• Specificity: Detects human DPPII/QPP/DPP7 in direct ELISAs and Western blots. In direct ELISAs and Western blots, 5% cross-reactivity with recombinant mouse DPP7 is observed.
• Source: N/A
• Isotype: IgG2a
• Clonality: Monoclonal
• Host: Rat
• Gene: DPP7
• Purity Statement: Protein A or G purified from hybridoma culture supernatant

Applications/Dilutions

• Dilutions:
  • Western Blot 1 ug/mL

Packaging, Storage & Formulations

• Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  12 months from date of receipt, -20 to -70 degreesC as supplied. 1 month, 2 to 8 degreesC under sterile conditions after reconstitution. 6 months, -20 to -70 degreesC under sterile conditions after reconstitution.
• Buffer: Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.
• Preservative: No Preservative
• Concentration: LYOPH
• Reconstitution Instructions: Reconstitute at 0.5 mg/mL in sterile PBS.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for DPPII/QPP/DPP7 Antibody (398024)

• carboxytripeptidase
• Dipeptidyl aminopeptidase II
• dipeptidyl arylamidase II
• dipeptidyl peptidase 2
• Dipeptidyl peptidase 7
• Dipeptidyl peptidase II
• dipeptidylpeptidase 7
• dipeptidyl-peptidase 7
• dipeptidyl-peptidase II
• DPP II
• DPP2
• DPP7
• DPPII
• EC 3.4.14.2
• QPP
• Quiescent cell proline dipeptidase

Background

Dipeptidyl-peptidase II (DPPII) is identical to quiescent cell proline dipeptidase (QPP) and dipeptidylpeptidase 7 (DPP7) (1, 2). It shares some substrate and cleavage specificity with DPPIV/CD26, DPP8, DPP9 and seprase/FAP (fibroblast activation protein), members of the S09 family of serine proteases. As prolyl proteases that cleave proteins and peptides after proline residues, these enzymes have high potential for drug discovery (3, 4). However, DPP7 is not a member of the S09 family, but a member of the S28 family that also includes lysosomal Pro-X carboxypeptidase/prolylcarboxypeptidase/PRCP and thymus-specific serine peptidase/PRSS16 (2). The human DPP7 precursor consists of a signal peptide (aa 1-21) and a mature chain (aa 22-492). The amino acid sequence of human DPP7 is 81%, 80% and 79% identical to that of mouse, rat and dog.

1. Underwood, R. et al. (1999) J. Biol. Chem. 274:34053.
2. Maes, M.B. et al. (2005) Biochem. J. 386:315.
3. Rosenblum, J.S. and J.W. Kozarich (2003) Curr. Opin. Chem. Biol. 7:496.
4. Lankas, G.R. et al. (2005) Diabetes 54:2988.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: DPP7
• Uniprot:
  • AAH11907()