DPPII/QPP/DPP7 Antibody (398024) [Alexa Fluor™ Plus 555]

• Reactivity: Hu
• Clone: 398024
• Clonality: Monoclonal
• Host: Rat
• Conjugate: Alexa Fluor Plus 555

DPPII/QPP/DPP7 Antibody (398024) [Alexa Fluor™ Plus 555] Summary

• Specificity: Detects human DPPII/QPP/DPP7 in direct ELISAs and Western blots. In direct ELISAs and Western blots, 5% cross‑reactivity with recombinant mouse DPP7 is observed.
• Isotype: IgG2a
• Clonality: Monoclonal
• Host: Rat

Packaging, Storage & Formulations

• Storage: Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied
• Buffer: Supplied 0.2 mg/mL in a saline solution containing BSA and Sodium Azide.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for DPPII/QPP/DPP7 Antibody (398024) [Alexa Fluor™ Plus 555]

• carboxytripeptidase
• Dipeptidyl aminopeptidase II
• dipeptidyl arylamidase II
• dipeptidyl peptidase 2
• Dipeptidyl peptidase 7
• Dipeptidyl peptidase II
• dipeptidylpeptidase 7
• dipeptidyl-peptidase 7
• dipeptidyl-peptidase II
• DPP II
• DPP2
• DPP7
• DPPII
• EC 3.4.14.2
• QPP
• Quiescent cell proline dipeptidase

Background

Dipeptidyl-peptidase II (DPPII) is identical to quiescent cell proline dipeptidase (QPP) and dipeptidylpeptidase 7 (DPP7) (1, 2). It shares some substrate and cleavage specificity with DPPIV/CD26, DPP8, DPP9 and seprase/FAP (fibroblast activation protein), members of the S09 family of serine proteases. As prolyl proteases that cleave proteins and peptides after proline residues, these enzymes have high potential for drug discovery (3, 4). However, DPP7 is not a member of the S09 family, but a member of the S28 family that also includes lysosomal Pro‑X carboxypeptidase/prolylcarboxypeptidase/PRCP and thymus-specific serine peptidase/PRSS16 (2). The human DPP7 precursor consists of a signal peptide (aa 1‑21) and a mature chain (aa 22‑492). The amino acid sequence of human DPP7 is 81%, 80% and 79% identical to that of mouse, rat and dog.

1. Underwood, R. et al. (1999) J. Biol. Chem. 274:34053.
2. Maes, M.B. et al. (2005) Biochem. J. 386:315.
3. Rosenblum, J.S. and J.W. Kozarich (2003) Curr. Opin. Chem. Biol. 7:496.
4. Lankas, G.R. et al. (2005) Diabetes 54:2988.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.