DPP6 Antibody

Immunohistochemistry-Paraffin: DPP6 Antibody [NB110-55517] - Analysis of anti-DPP6 antibody with human brain, neurons at 20 ug/ml.

Product Discontinued

DPP6 Antibody Summary

• Immunogen: Synthetic 18 amino acid peptide from extracellular domain of human DPP6.
• Specificity: Human DPP6. BLAST analysis of the peptide immunogen showed no homology with other human proteins.
• Predicted Species: Porcine (94%), Chimpanzee (100%), Opossum (94%). Backed by our 100% Guarantee.
• Isotype: IgG
• Clonality: Polyclonal
• Host: Rabbit
• Gene: DPP6
• Purity: Immunogen affinity purified

Applications/Dilutions

• Dilutions:
  • Immunohistochemistry
  • Immunohistochemistry-Paraffin 20 ug/ml
• Application Notes: ICC: Unsuccessful results on Mouse hippocampal cultured neurons is reported by anonymous customer.

Reactivity Notes

Predicted cross-reactivity based on sequence identity: Gorilla (100%), Gibbon (100%), Marmoset (100%), Turkey (89%), Chicken (89%), Zebrafish (89%).

Packaging, Storage & Formulations

• Storage: Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
• Buffer: PBS
• Preservative: 0.1% Sodium Azide
• Concentration: 1 mg/ml
• Purity: Immunogen affinity purified

Alternate Names for DPP6 Antibody

• dipeptidyl aminopeptidase IV-related protein
• dipeptidyl aminopeptidase-like protein 6
• Dipeptidyl aminopeptidase-related protein
• Dipeptidyl peptidase 6
• Dipeptidyl peptidase IV-like protein
• dipeptidyl peptidase IV-related protein
• Dipeptidyl peptidase VI
• dipeptidylpeptidase 6
• dipeptidyl-peptidase 6
• dipeptidylpeptidase VI
• DPP VI
• DPP6
• DPPX
• DPPXFLJ55680
• MGC46605
• VF2

Background

DPP6 (DPPX, also known as potassium channel accelerating factor Dppx) is a Type-II serine proteinase of the clan SC. The clan SC proteinases have a catalytic triad of Ser-Asp-His, and like other Serine proteinases, the active site serine is in a Gly-Xaa-Ser-Xaa -Gly orientation. DPP6 has an Asp instead of Ser in the catalytic site. DPP6 is a member of a broader family of dipeptidyl peptidases including DPP4, FAP/Seprase, DPP2, DPP8, DPP9, DPP10, which have differing substrate specificity and tissue localizations. The surface-bound DPP6 is a homodimer, and cleavage of in the stalk region releases a shed form of DPP6. The shed is the form found in serum. DPP6 has been found in highest abundance in the brain, but also in the kidney, liver and lung.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Publications for DPP6 Antibody (NB110-55517)(1)

Publication using NB110-55517

• Prunotto M, Farina A, Lane L et al. Proteomic analysis of podocyte exosome-enriched fraction from normal human urine. J Proteomics. 2013-01-30 [PMID: 23376485] (IHC-P, Human)

Bioinformatics

• Gene Symbol: DPP6
• Entrez:
  • 1804(Human)
• Uniprot:
  • P42658()