DOK7 Antibody (651601) [Alexa Fluor® 488]

• Reactivity: Hu
• Applications: ICC/IF
• Clone: 651601
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: Alexa Fluor 488

DOK7 Antibody (651601) [Alexa Fluor® 488] Summary

• Immunogen: E. coli-derived recombinant human DOK7
  Ala179-Pro299
  Accession # Q18PE1
• Specificity: Detects human DOK7 in direct ELISAs.
• Isotype: IgG2a
• Clonality: Monoclonal
• Host: Mouse
• Purity Statement: Protein A or G purified

Applications/Dilutions

• Dilutions:
  • Immunocytochemistry

Packaging, Storage & Formulations

• Storage: Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied
• Buffer: Supplied 0.2mg/ml in 1X PBS with RDF1 and 0.09% Sodium Azide

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for DOK7 Antibody (651601) [Alexa Fluor® 488]

• C4orf25
• C4orf25chromosome 4 open reading frame 25
• CMS1B
• docking protein 7
• DOK7
• Dok-7
• Downstream of tyrosine kinase 7
• FLJ33718
• FLJ39137
• FLJ90556
• protein Dok-7

Background

DOK7 (Downstream of kinase 7) is a 55 kDa member of the DOK family of cytoplasmic adaptor proteins. It links the acetylcholine receptor and the receptor tyrosine kinase MuSK in skeletal and cardiac muscle. Mutations can cause familial myasthenic syndromes. The 504 amino acid (aa) human DOK7 contains pleckstrin homology (aa 7-109) and phosphotyrosine-binding (PTK, aa 125-236) and SH2 domains, and a C-terminal nuclear export signal. Splicing isoforms of 255, 608 and 366 aa diverge at aa 175 or 500, or have 40 divergent aa replacing aa 1-178, respectively. Within aa 179-299, human DOK7 shares 92% and 93% aa identity with mouse and rat DOK7, respectively.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.