DOCK2 Antibody [Alexa Fluor® 488]

• Reactivity: Hu
• Applications: WB
• Clonality: Polyclonal
• Host: Goat
• Conjugate: Alexa Fluor 488

DOCK2 Antibody [Alexa Fluor® 488] Summary

• Immunogen: E. coli-derived recombinant human DOCK2
  Gly420-Gly642
  Accession # Q92608
• Specificity: Detects human DOCK2 in Western blots.
• Isotype: IgG
• Clonality: Polyclonal
• Host: Goat
• Purity Statement: Antigen Affinity-purified

Applications/Dilutions

• Dilutions:
  • Western Blot

Packaging, Storage & Formulations

• Storage: Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied
• Buffer: Supplied 0.2mg/ml in 1X PBS with RDF1 and 0.09% Sodium Azide

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for DOCK2 Antibody [Alexa Fluor® 488]

• dedicator of cytokinesis 2
• dedicator of cytokinesis protein 2
• DOCK2
• FLJ46592
• KIAA0209dedicator of cyto-kinesis 2

Background

DOCK2 (Dedicator of cytokinesis protein 2) is a member of the DOCK-A family, DOCK180 superfamily of proteins. Its predicted molecular weight is 210 kDa, although it may run approximately at 190 kDa in SDS-PAGE. It is found in hematopoietic cell types, and regulates the activity of the GTPases Rac-1 and -2. Human DOCK2 is 1830 amino acids (aa) in length. It contains one SH3 domain (aa 8‑69), a DHR-1 region that localizes DOCK2 to the plasma membrane (aa 420‑662), and a DHR-2 domain that binds to nucleotide-free GTPases and shows GEF activity (aa 1115‑1621). There are two isoform variants, one that shows a 38 aa substitution for Tyr1405, and a second that shows a start site at Met450 with accompanying deletions of aa 462‑494 and 630‑766, and a 22 aa substitution for aa 934‑1830. Over aa 420‑642, human DOCK2 shares 96% aa identity to mouse DOCK2.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.