DOCK1 Antibody [DyLight 350]

• Reactivity: Hu, Rt
• Applications: WB
• Clonality: Polyclonal
• Host: Goat
• Conjugate: DyLight 350

DOCK1 Antibody [DyLight 350] Summary

• Immunogen: E. coli-derived recombinant human DOCK1
  Gly422-Ser666
  Accession # Q14185
• Specificity: Detects recombinant human DOCK1 in direct ELISAs. Detects human and rat DOCK1 in Western blots.
• Isotype: IgG
• Clonality: Polyclonal
• Host: Goat
• Gene: DOCK1
• Purity: Antigen Affinity-purified

Applications/Dilutions

• Dilutions:
  • Western Blot
• Application Notes: Optimal dilution of this antibody should be experimentally determined.

Packaging, Storage & Formulations

• Storage: Store at 4C in the dark.
• Buffer: 50mM Sodium Borate
• Preservative: 0.05% Sodium Azide
• Purity: Antigen Affinity-purified

Notes

DyLight (R) is a trademark of Thermo Fisher Scientific Inc. and its subsidiaries.

Alternate Names for DOCK1 Antibody [DyLight 350]

• 180 kDa protein downstream of CRK
• ced5
• dedicator of cytokinesis 1
• dedicator of cyto-kinesis 1
• DOCK1
• DOCK180
• DOCK180dedicator of cytokinesis protein 1
• DOwnstream of CrK

Background

DOCK80 is a non-conventional Rho-guanine nucleotide exchange factor (Rho-GEF) that functions to activate the small GTPases Rac and Cdc42. It is a member of the CZH (CDM-zizimin homology) family of proteins that contain two highly conserved domains, CZH1 and CZH2. Dock180 functions to activate Rac and regulate cell adhesion, cell spreading, migration and phagocytosis.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: DOCK1