DLL3 Antibody (SC16.15) - Chimeric - BSA Free

• Reactivity: Hu, Mu, Rt, Pm-Cm
• Applications: ELISA, Flow, Func
• Clone: SC16.15
• Clonality: Monoclonal
• Host: Rabbit
• Conjugate: Unconjugated
• Format: BSA Free
• Concentration: 1 mg/ml

DLL3 Antibody (SC16.15) - Chimeric - BSA Free Summary

• Description: This chimeric rabbit antibody was made using the variable domain sequences of the original Mouse IgG1 format, for improved compatibility with existing reagents, assays and techniques.
• Additional Information: Recombinant Monoclonal Antibody
• Immunogen: Three strains of mice (Balb/c, CD-1 and FVB) were immunized with recombinant human DLL3-Fc or with human DLL3-His fusion constructs (Uniprot#: Q9NYJ7)
• Specificity: This antibody binds human DLL3 in the N-terminal domain
• Isotype: IgG Kappa
• Clonality: Monoclonal
• Host: Rabbit
• Gene: DLL3
• Purity: Protein A purified

Applications/Dilutions

• Dilutions:
  • ELISA
  • Flow Cytometry
  • Functional
• Application Notes: This antibody can mediate killing of tumor cells expressing DLL3 and facilitate the delivery of cytotoxic agents to live cells, in an vitro cell killing assay. This antibody was capable of killing OV26 cells, an ovarian NET NTX tumor, with a sub-picomolar EC50 (e.g. 0.14 pM).

Packaging, Storage & Formulations

• Storage: Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
• Buffer: PBS
• Preservative: 0.02% Proclin 300
• Concentration: 1 mg/ml
• Purity: Protein A purified

Alternate Names for DLL3 Antibody (SC16.15) - Chimeric - BSA Free

• delta (Drosophila)-like 3
• Delta3
• delta-like 3 (Drosophila)
• delta-like protein 3
• DLL3
• Drosophila Delta homolog 3
• Pudgy
• SCDO1
• SCDO1delta3

Background

The DLL3 gene encodes a member of the delta protein ligand family. This family functions as Notch ligands that are characterized by a DSL domain, EGF repeats, and a transmembrane domain. Mutations in this gene cause autosomal recessive spondylocostal dysostos

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: DLL3