Desmoplakin Antibody

Product Discontinued

Desmoplakin Antibody Summary

• Immunogen: Peptide with sequence C-SQERTVKDQDITR corresponding to internal region according to NP_004406.2.
• Epitope: SQERTVKDQDITR - internal region
• Marker: Desmosomes Marker
• Specificity: This antibody is expected to recognize reported isoform I (NP_004406.2) only.
• Isotype: IgG
• Clonality: Polyclonal
• Host: Goat
• Gene: DSP
• Purity: Immunogen affinity purified

Applications/Dilutions

• Dilutions:
  • Peptide ELISA Detection limit 1:4000
• Application Notes: WB: Preliminary experiments in lysates of HEK293, HeLa and NIH3T3 gave no specific signal but low background.

Packaging, Storage & Formulations

• Storage: Store at -20C. Avoid freeze-thaw cycles.
• Buffer: Tris saline (20 mM Tris pH 7.3, 150 mM NaCl), 0.5% BSA
• Preservative: 0.02% Sodium Azide
• Concentration: 0.5 mg/ml
• Purity: Immunogen affinity purified

Notes

Please note, this antibody is considered Innovators Grade. Innovators Grade antibodies are generally unvalidated and require additional characterization for most new species/applications. Novus has made these antibodies available through our Innovators Reward program. Complete an online review with image, detailing your positive or negative results. In return, you receive a discount voucher for 100% of the purchase price of the reviewed product. Please contact us at innovators@novusbio.com for more details.

Alternate Names for Desmoplakin Antibody

• 250/210 kDa paraneoplastic pemphigus antigen
• DCWHKTA
• desmoplakin (DPI, DPII)
• desmoplakin I
• desmoplakin II
• Desmoplakin
• DP
• DPI
• DPII
• DSP
• KPPS2
• PPKS2

Background

Major high molecular weight protein of desmosomes. Involved in the organization of the desmosomal cadherin-plakoglobin complexes into discrete plasma membrane domains and in the anchoring of intermediate filaments to the desmosomes.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Publications for Desmoplakin Antibody (NBP1-49880)(1)

Publication using NBP1-49880

• Barahona-Dussault C, Benito B, Campuzano O et al. Role of genetic testing in arrhythmogenic right ventricular cardiomyopathy/dysplasia. Clin Genet 2010-01-01 [PMID: 19863551]

Bioinformatics

• Gene Symbol: DSP
• Entrez:
  • 1832(Human)
  • 109620(Mouse)
  • 306871(Rat)
• Uniprot:
  • NP_004406.2(Human)