DAB2 Antibody

Product Discontinued

DAB2 Antibody Summary

• Immunogen: Synthetic peptide C-SEMYRDPFGNPFA, representing the C-Terminus of the protein sequence according to NP_001334.
• Isotype: IgG
• Clonality: Polyclonal
• Host: Goat
• Gene: DAB2
• Purity: Immunogen affinity purified

Applications/Dilutions

• Dilutions:
  • Peptide ELISA detection limit 1:32000
  • Western Blot 1:1000
• Application Notes: Approx 75kDa band observed in human kidney lysates (calculated MW of 82.6kDa according to NP_001334.1).
• Control:

  DAB2 Overexpression Lysate

Reactivity Notes

Cross reacts with Human. Expected from sequence similarity: Mouse, Rat and Dog.

Packaging, Storage & Formulations

• Storage: Store at -20C. Avoid freeze-thaw cycles.
• Buffer: Tris (pH 7.3), 0.5% BSA
• Preservative: 0.02% Sodium Azide
• Concentration: 0.5 mg/ml
• Purity: Immunogen affinity purified

Alternate Names for DAB2 Antibody

• DAB2
• Differentially-expressed protein 2
• disabled (Drosophila) homolog 2 (mitogen-responsive phosphoprotein)
• disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila)
• Disabled-2
• DOC2
• DOC-2DOC2disabled homolog 2
• FLJ26626
• mitogen-responsive phosphoprotein

Background

DAB2 mRNA is expressed in normal ovarian epithelial cells but is down-regulated or absent from ovarian carcinoma cell lines. The 770-amino acid predicted protein has an overall 83% identity with the mouse p96 protein, a putative mitogen-responsive phosphoprotein; homology is strongest in the amino-terminal end of the protein in a region corresponding to the phosphotyrosine interaction domain. The down-regulation of DAB2 may play an important role in ovarian carcinogenesis. This gene was initially named DOC2 (for Differentially expressed in Ovarian Cancer) and is distinct from the DOC2A and DOC2B genes (for double C2-like domains, alpha and beta).

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: DAB2
• Entrez:
  • 1601(Human)
• Uniprot:
  • NP_001334.(Human)