Cytokeratin 3/12 Antibody (1.BB.787)

Product Discontinued

Cytokeratin 3/12 Antibody (1.BB.787) Summary

• Immunogen: Human corneal epithelial keratin
• Specificity: Recognizes the 64kD polypeptide (cytokeratin 3) of human and rabbit corneal epithelial keratin. An excellent marker for studying corneal epithelial-type differentiation. Recognizes bovine snout epithelium and rabbit lip epithelium.
• Isotype: IgG1
• Clonality: Monoclonal
• Host: Mouse
• Gene: KRT3
• Purity: Immunogen affinity purified

Applications/Dilutions

• Dilutions:
  • Immunohistochemistry 1:10-1:500
  • Immunohistochemistry-Frozen 1:10-1:500
  • Western Blot 1:100-1:2000

Reactivity Notes

Cross reacts with Human.

Packaging, Storage & Formulations

• Storage: Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
• Buffer: PBS (pH 7.2) and 40% Glycerol
• Preservative: 0.01% Sodium Azide
• Concentration: 0.5 mg/ml
• Purity: Immunogen affinity purified

Alternate Names for Cytokeratin 3/12 Antibody (1.BB.787)

• CK3
• CK-3
• Cytokeratin-3
• FLJ95909
• K3cytokeratin 3
• keratin 3
• keratin, type II cytoskeletal 3,65 kDa cytokeratin
• Keratin-3
• Type-II keratin Kb3

Background

The protein encoded by the Cytokeratin 3 / 12 gene is a member of the keratin gene family. The type II cytokeratins consist of basic or neutral proteins which are arranged in pairs of heterotypic keratin chains coexpressed during differentiation of simple and stratified epithelial tissues. This type II cytokeratin is specifically expressed in the corneal epithelium with family member KRT12 and mutations in these genes have been associated with Meesmann's Corneal Dystrophy. The type II cytokeratins are clustered in a region of chromosome 12q12-q13. (provided by RefSeq)

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: KRT3
• Entrez:
  • 3850(Human)