Immunocytochemistry/ Immunofluorescence: Cysteine Conjugate beta-Lyase/CCBL1 Antibody [NBP1-83317] - Immunofluorescent staining of human cell line U-2 OS shows localization to cytosol.
Immunohistochemistry-Paraffin: Cysteine Conjugate beta-Lyase/CCBL1 Antibody [NBP1-83317] - Staining of human stomach shows strong cytoplasmic positivity in glandular cells.
This antibody was developed against Recombinant Protein corresponding to amino acids: LVDEGDEVIIIEPFFDCYEPMTMMAGGRPVFVSLKPGPIQNGELGSSSNWQLDPMELAGKFTSRTKALVLNTPNNPLGKVF
Isotype
IgG
Clonality
Polyclonal
Host
Rabbit
Gene
KYAT1
Purity
Affinity purified
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IHC, WB reported in scientific literature (PMID: 23451256). For IHC-Paraffin, HIER pH 6 retrieval is recommended. Immunocytochemistry/Immunofluorescence Fixation Permeabilization: Use PFA/Triton X-100.
Immunogen displays the following percentage of sequence identity for non-tested species: Mouse (81%), Rat (80%). Reactivity reported in scientific literature (PMID: 23451256)
Packaging, Storage & Formulations
Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
PBS (pH 7.2) and 40% Glycerol
Preservative
0.02% Sodium Azide
Purity
Affinity purified
Alternate Names for Cysteine Conjugate beta-Lyase/CCBL1 Antibody - BSA Free
CCBL1
Cysteine Conjugate betaLyase
Cysteine Conjugate beta-Lyase
cysteine conjugate-beta lyase, cytoplasmic
cysteine conjugate-beta lyase; cytoplasmic (glutamine transaminase K
Cysteine-S-conjugate beta-lyase
EC 2.6.1.64
EC 2.6.1.7
EC 4.4.1.13
FLJ95217
Glutamine Transaminase K
glutamine-phenylpyruvate aminotransferase
Glutamine--phenylpyruvate transaminase
GTKMGC29624
KAT1
KATI
KATIbeta-lysase, kidney
Kyneurenine Aminotransferase I
kyneurenine aminotransferase
kyneurenine aminotransferase)
Kynurenine aminotransferase I
kynurenine--oxoglutarate transaminase 1
Kynurenine--oxoglutarate transaminase I
Background
CCBL1 encodes a cytosolic enzyme that is responsible for the metabolism of cysteine conjugates of certain halogenated alkenes and alkanes. This metabolism can form reactive metabolites leading to nephrotoxicity and neurotoxicity. Increased levels of this enzyme have been linked to schizophrenia. Multiple transcript variants that encode different isoforms have been identified for this gene.
Limitations
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.
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