Cyr61/CCN1 Antibody [DyLight 405]


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Product Details

Reactivity Hu, RbSpecies Glossary
Applications WB, B/N, ICC/IF, IHC-P
Please see the vial label for concentration. If unlisted please contact technical services.

Cyr61/CCN1 Antibody [DyLight 405] Summary

A synthetic peptide made to the human CYR61 protein sequence (between residues 150-250). [UniProt# O00622]
Immunogen affinity purified
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Packaging, Storage & Formulations

Store at 4C in the dark.
DyLight 405
DyLight 405 (A=400, E=420)
50mM Sodium Borate
0.05% Sodium Azide
Please see the vial label for concentration. If unlisted please contact technical services.
Immunogen affinity purified


  • Western Blot 1:200
  • Blocking/Neutralizing 50-200 molar excess
  • Immunocytochemistry/Immunofluorescence 1:10-1:500
  • Immunohistochemistry-Paraffin 1:100
Application Notes
This CYR61 antibody is useful for Blocking/Neutralizing, Western Blot, Immunocytochemistry/Immunofluorescence, and Immunohistochemistry-paraffin embedded sections. Immunohistochemistry was reported in scientific literature. In Western blot a band is observed at ~37 kDa, representing the processed form of CYR61 protein. Antigen retrieval was not used on the IHC-P pictures below. IF/ICC (PMID 18202125), Blocking/Neutralizing (PMID 22282654).

The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.
Theoretical MW
37 kDa

Reactivity Notes

Human. The immunogen sequence has 88% homology to rat and mouse. Rabbit reactivity reported in scientific literature (PMID: 22401280)


Dylight (R) is a trademark of Thermo Fisher Scientific Inc. and its subsidiaries.

Alternate Names for Cyr61/CCN1 Antibody [DyLight 405]

  • CCN family member 1
  • CCN1
  • CCN1IGF-binding protein 10
  • Cysteine-rich angiogenic inducer 61
  • cysteine-rich, angiogenic inducer, 61
  • GIG1
  • GIG1cysteine-rich heparin-binding protein 61
  • IBP-10
  • IGFBP-10
  • IGFBP10cysteine-rich, anigogenic inducer, 61
  • Insulin-like growth factor-binding protein 10
  • protein CYR61
  • Protein GIG1


CYR61 (cysteine-rich angiogenic inducer 61), a heparin-binding growth factor, belongs to CCN family whose members are: cysteine-rich 61 (CYR61/CCN1), connective tIssue growth factor (CTGF/CCN2), nephroblastoma overexpressed (NOV/CCN3), and Wnt-induced secreted proteins-1 (WISP-1/CCN4), -2 (WISP-2/CCN5) and -3 (WISP-3/CCN6). CYR61 localizes intracellularly or associates with extracellular matrix at cell surfaces and its reported nuclear localization is surprising, since the primary structure of CYR61 does not include a classic nuclear localization sequence, however, like NOV, EGF, FGF, PDGF, angiogenin, PTHrP etc which lack afore-mentioned sequence, CYR61's nuclear presence may be correlated with transcriptional regulation, and/or mRNA transport. CYR61 plays a key role in wound healing by up-regulating the expression of several genes involved in angiogenesis, inflammation and matrix remodeling including VEGA-A, VEGA-C, MMP1, MMP3, TIMP1, uPA, PAI-1, integrins alpha-3 and alpha-5. CYR61 down-regulates the expression of alpha-1/alpha-2 subunits of collagen type-1 and promotes cell adhesion/adhesive signaling through integrin alpha-6/beta-1, cell migration through integrin alpha-v/beta-5 and cell proliferation through integrin alpha-v/beta-3. CYR61 has been reported to exert its diverse functions via cross-talk with/activating of Wnt, NFkB, AKT and tyrosine kinase signaling pathways.


This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Product General Protocols

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Video Protocols

WB Video Protocol
ICC/IF Video Protocol

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Secondary Antibodies


Isotype Controls

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Contact Information

Product PDFs


Gene Symbol CYR61

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