Cyclophilin 40 Antibody

Images

 
Western Blot: Cyclophilin 40 Antibody [NB120-3567] - Analysis of rat heart extract.
Western Blot: Cyclophilin 40 Antibody [NB120-3567] - Analysis of rat brain extract.

Product Details

Summary
Reactivity Hu, Mu, Rt, CaSpecies Glossary
Applications WB
Clonality
Polyclonal
Host
Rabbit
Conjugate
Unconjugated
Concentration
1 mg/ml

Order Details

Cyclophilin 40 Antibody Summary

Immunogen
Synthetic peptide corresponding to residues S(42) G N P L V Y L D V D A N(54) C of mature human CyPD.
Localization
Mitochondrial
Specificity
NB120-3567 detects cyclophilin D (CyPD) in rat, canine, mouse, and human tissues.
Isotype
IgG
Clonality
Polyclonal
Host
Rabbit
Gene
PPID
Purity
Immunogen affinity purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Western Blot 1 ug/ml
Application Notes
Successful WB usage. WB: Detects an approx. 15 kDa protein in rat liver and heart extract, and a ~37 kDa in rat brain extract.
Positive Control
Brain Lysate (NB820-59705)
Cyclophilin 40 Lysate (NBL1-14648)

Packaging, Storage & Formulations

Storage
Store at -20C. Avoid freeze-thaw cycles.
Buffer
PBS
Preservative
0.05% Sodium Azide
Concentration
1 mg/ml
Purity
Immunogen affinity purified

Alternate Names for Cyclophilin 40 Antibody

  • 40 kDa peptidyl-prolyl cis-trans isomerase D
  • 40 kDa peptidyl-prolyl cis-trans isomerase
  • cyclophilin D
  • cyclophilin-40
  • Cyclophilin-related protein
  • CYP40
  • CYP-40cyclophilin 40
  • CYPD
  • EC 5.2.1.8
  • MGC33096
  • peptidyl-prolyl cis-trans isomerase D
  • peptidylprolyl isomerase D (cyclophilin D)
  • peptidylprolyl isomerase D
  • PPIase D
  • Rotamase D

Background

Cyclophilin D (CyPD) is a member of the immunophilin family of proteins. Immunophilins are a family of soluble cytosolic receptors capable of binding to one of two major immunosuppressant agents - cyclosporin A (CsA) or FK506. Proteins which bind FK506 are termed FK506 Binding Proteins (FKBP's) and those which bind cyclosporin A are called cyclophilins (CyP). Immunophilins function as peptidyl prolyl cis-trans-isomerases (PPIase) whose activity is inhibited by their respective immunosuppressant compounds. As PPIase's, immunophilins accelerate folding of some proteins both in vivo and in vitro by catalyzing slow steps in the initial folding and rearrangement of proline containing proteins. CyPD is located in the inter-membrane space of the mitochondria where it has been shown to be an integral member of the permeability transition pore complex which also includes the voltage dependent anion channel (VDAC) and the adenine nucleotide translocator (ANT).

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Positive Control Lysate(s)

Secondary Antibodies

 

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Bioinformatics

Gene Symbol PPID
Entrez