Cyclophilin 40 Products

Antibodies
Cyclophilin 40 Antibody
Cyclophilin 40 Antibody
NB120-3562
Species: Hu, Mu, Rt, Bv, Ch, Pm, Rb
Applications: WB, Flow, GS, ICC/IF, IHC, IHC-Fr, IP
Host: Rabbit Polyclonal
Cyclophilin 40 Antibody
Cyclophilin 40 Antibody
H00005481-B01P
Species: Hu, Mu, Rt
Applications: WB, ELISA
Host: Mouse Polyclonal
Cyclophilin 40 Antibody
Cyclophilin 40 Antibody
NBP1-85364
Species: Hu, Mouse, Rat
Applications: WB, ICC/IF, IHC, IHC-P
Host: Rabbit Polyclonal
Antibody Pairs
Cyclophilin 40 Antibody Pair
Cyclophilin 40 Antibody Pair
H00005481-AP22
Species: Hu
Applications: S-ELISA
Cyclophilin 40 Antibody Pair
Cyclophilin 40 Antibody Pair
H00005481-PW2
Species: Hu
Applications: WB, IP
Lysates
Cyclophilin 40 Overexpression ...
Cyclophilin 40 Overexpression Lysa...
H00005481-T01
Species: Hu
Applications: WB
Cyclophilin 40 Overexpression ...
Cyclophilin 40 Overexpression Lysa...
NBL1-14648
Applications: WB
Proteins
Cyclophilin 40 Recombinant Pr ...
Cyclophilin 40 Recombinant Protein...
NBP1-85363PEP
Species: Hu
Applications: AC
Cyclophilin 40 Recombinant Pr ...
Cyclophilin 40 Recombinant Protein...
NBP1-85364PEP
Species: Hu
Applications: AC
Cyclophilin 40 Recombinant Pr ...
Cyclophilin 40 Recombinant Protein
NBC1-18427
Species: Hu
Applications: PAGE

Description

Immunophilins are a family of soluble cytosolic receptors capable of binding to one of two major immunosuppressant agents: cyclosporin A (CsA) or FK506. Proteins that bind FK506 are termed FK506 Binding Proteins (FKBPs) and those that bind cyclosporin A are called cyclophilins (CyP). Both CyP:CsA and FKBP:FK506 complexes have been shown to inhibit calcineurin, a calcium and calmodulin dependent protein phosphatase which has been implicated as an important signaling enzyme in T-cell activation, providing a possible mechanism of immunosuppression by CsA and FK506. Immunophilins function as peptidyl prolyl cis-trans-isomerases (PPIase) whose activity is inhibited by their respective immunosuppressant compounds. As PPIase's, immunophilins accelerate folding of some proteins both in vivo and in vitro by catalyzing slow steps in the initial folding and rearrangement of proline containing proteins. CyP 40, a 40 kDa protein, shares significant homology with smaller CyPA (CyP 18) and FKBP59. CyP 40 exhibits the characteristic CsA binding and isomerase activity of CyP 18, though these activities appear to be less with CyP 40 than with Cyp 18. Like FKBP59, CyP 40 has been found in progesterone receptor complexes. CyP 40 is expressed at similar levels in many tissues.

Bioinformatics

Entrez Human
Mouse
Rat
Uniprot Human
Human
Human
Human
Product By Gene ID 5481
Alternate Names
  • 40 kDa peptidyl-prolyl cis-trans isomerase D
  • Cyclophilin-40
  • peptidylprolyl isomerase D (cyclophilin D)
  • CYP40
  • EC 5.2.1.8
  • 40 kDa peptidyl-prolyl cis-trans isomerase
  • PPIase D
  • peptidyl-prolyl cis-trans isomerase D
  • CYPD
  • cyclophilin-40
  • Rotamase D
  • cyclophilin D
  • Cyclophilin-related protein
  • CYP-40cyclophilin 40
  • MGC33096
  • peptidylprolyl isomerase D

Research Areas for Cyclophilin 40

Find related products by research area and learn more about each of the different research areas below.

Immunology

PTMs for Cyclophilin 40

Learn more about PTMs related to Cyclophilin 40.

Nitration
Carboxylation
Deacetylation

Bioinformatics Tool for Cyclophilin 40

Discover related pathways, diseases and genes to Cyclophilin 40. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
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