Cyclin T1 Antibody

Product Discontinued

Cyclin T1 Antibody Summary

• Immunogen: CCNT1 (NP_001231, 321 a.a. - 420 a.a.) partial recombinant protein with GST tag. SNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAY
• Specificity: CCNT1 - cyclin T1
• Clonality: Polyclonal
• Host: Mouse
• Gene: CCNT1
• Purity: Unpurified

Applications/Dilutions

• Dilutions:
  • ELISA
• Application Notes: This antibody is useful for ELISA.

Packaging, Storage & Formulations

• Storage: Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.
• Buffer: 50 % glycerol
• Preservative: No Preservative
• Purity: Unpurified

Notes

This product is produced by and distributed for Abnova, a company based in Taiwan.

Alternate Names for Cyclin T1 Antibody

• CCNT
• CCNT1
• CCNTcyclin-T
• CDK9-associated C-type protein
• cyclin C-related protein
• cyclin T1
• cyclin T1b
• Cyclin-T
• cyclin-T1
• CYCT1
• HIVE1
• human immunodeficiency virus type 1 (HIV-1) expression (elevated) 1
• Human immunodeficiency virus-1 expression
• subunit of positive elongation transcription factor b

Background

The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin tightly associates with CDK9 kinase, and was found to be a major subunit of the transcription elongation factor p-TEFb. The kinase complex containing this cyclin and the elongation factor can interact with, and act as a cofactor of human immunodeficiency virus type 1 (HIV-1) Tat protein, and was shown to be both necessary and sufficient for full activation of viral transcription. This cyclin and its kinase partner were also found to be involved in the phosphorylation and regulation of the carboxy-terminal domain (CTD) of the largest RNA polymerase II subunit.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: CCNT1
• Entrez:
  • 904(Human)
• OMIM:
  • 602506(Human)
• Uniprot:
  • NP_001231(Human)