Recombinant Human CTDSPL His Protein

Recombinant Human CTDSPL Protein [NBP1-99109]

• Reactivity: Hu
• Applications: PAGE
• Concentration: 0.5 mg/ml

Recombinant Human CTDSPL His Protein Summary

• Description: A recombinant protein with a N-Terminal His-tag and corresponding to the amino acids 82-265 of Human CTDSPL
  
  

  Source: E.coli

  Amino Acid Sequence: MGSSHHHHHH SSGLVPRGSH MGSHMKYLLP EVTVLDYGKK CVVIDLDETL VHSSFKPISN ADFIVPVEID GTIHQVYVLK RPHVDEFLQR MGQLFECVLF TASLAKYADP VADLLDRWGV FRARLFRESC VFHRGNYVKD LSRLGRELSK VIIVDNSPAS YIFHPENAVP VQSWFDDMTD TELLDLIPFF EGLSREDDVY SMLHRLCNR

• Source: E. coli
• Protein/Peptide Type: Recombinant Protein
• Gene: CTDSPL
• Purity: >90%, by SDS-PAGE

Applications/Dilutions

• Dilutions:
  • SDS-Page
• Theoretical MW: 23.9 kDa.
  Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Packaging, Storage & Formulations

• Storage: Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
• Buffer: 20 mM Tris-HCl buffer (pH8.0), 40% glycerol, 0.15 M NaCl, 1 mM DTT
• Preservative: No Preservative
• Concentration: 0.5 mg/ml
• Purity: >90%, by SDS-PAGE

Alternate Names for Recombinant Human CTDSPL His Protein

• C3orf8
• Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 3
• CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) smallphosphatase-like
• CTD small phosphatase-like protein
• CTDSP-like
• EC 3.1.3
• HYA22
• NIF1
• NIFL
• NIF-like protein
• NLI-interacting factor 1
• Nuclear LIM interactor-interacting factor 1
• Protein YA22
• PSR1
• RB protein serine phosphatase from chromosome 3
• RBSP3EC 3.1.3.16
• SCP3chromosome 3 open reading frame 8
• Small CTD phosphatase 3
• Small C-terminal domain phosphatase 3
• YA22

Background

CTDSPL, also known as CTD small phosphatase-like protein, preferentially catalyzes the dephosphorylation of 'Ser-5' within the tandem 7 residues repeats in the C-terminal domain (CTD) of the largest RNA polymerase II subunit POLR2A. Recombinant human CTDSPL protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Peptides and proteins are guaranteed for 3 months from date of receipt.

Publications for CTDSPL Recombinant Protein (NBP1-99109)(1)

Publication using NBP1-99109

• Lv X, Lu X, Cao J et al. Modulation of the proteostasis network promotes tumor resistance to oncogenic KRAS inhibitors Science (New York, N.Y.) 2023-09-08 [PMID: 37676964]

Bioinformatics

• Gene Symbol: CTDSPL