CSB Recombinant Enzymes

• Reactivity: Hu
• Applications: NULL

CSB Recombinant Enzymes Summary

• Description: Human CSB (aa 1-1493) fused to 6xHis and FLAG-tag at the N-terminus. (Uniprot: Q03468-1)
• Source: Sf 9 (baculovirus)
• Protein/Peptide Type: Recombinant Enzymes
• Gene: ERCC6
• Purity: Immunogen affinity purified

Applications/Dilutions

• Dilutions:
  • N/A

Packaging, Storage & Formulations

• Storage: Store at -80C. Avoid freeze-thaw cycles.
• Buffer: 20 mM Tris-HCl, pH 7.9, 150 mM NaCl, 15% glycerol, 2 mM MgCl2, 0.2 mM EDTA, 1 mM DTT, 10 mM beta-glycerophospate, 0.4 mM PMSF, 1 mM benzamidine and 0.4 mg/ml recombinant human insulin
• Preservative: No Preservative
• Purity: Immunogen affinity purified

Alternate Names for CSB Recombinant Enzymes

• ARMD5
• ATP-dependent helicase ERCC6
• CKN2
• Cockayne syndrome group B protein
• Cockayne syndrome protein CSB
• COFS
• COFS1
• CSBCockayne syndrome B protein
• DNA excision repair protein ERCC-6
• EC 3.6.1
• EC 3.6.4.-
• excision repair cross-complementing rodent repair deficiency, complementationgroup 6
• Rad26 homolog
• RAD26

Background

ERCC6, also known as Cockayne syndrome B protein, is involved in DNA repair in response to UV exposure. ERCC6 has been reported to display ATPase and helicase activity and functions as a transcriptional regulator. Mutations in ERCC6 are the cause of Cockayne syndrome type B (CSB), cerebro-oculo-facio-skeletal syndrome type 1 (COFS1), De Sanctis-Cacchione syndrome (DCS), age-related macular degeneration type 5 (ARMD5), and UV-sensitive syndrome (UVS).

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Peptides and proteins are guaranteed for 3 months from date of receipt.

Bioinformatics

• Gene Symbol: ERCC6