CRHR2/CRF2 Antibody [DyLight 405]

• Reactivity: Hu, Mu, Rt, Bv, Ca, Ch, Ma, Pm
• Applications: WB, ICC/IF
• Clonality: Polyclonal
• Host: Rabbit
• Conjugate: DyLight 405

CRHR2/CRF2 Antibody [DyLight 405] Summary

• Immunogen: A portion of amino acids 75-125 of human CRHR2 was used as the immunogen.
• Specificity: There are three isoforms of CRHR2 in human: alpha is 411 amino acids, beta is 438 amino acids, and gamma is 397 amino acids.
• Predicted Species: Primate (94%). Backed by our 100% Guarantee.
• Isotype: IgG
• Clonality: Polyclonal
• Host: Rabbit
• Gene: CRHR2
• Purity: Protein G purified

Applications/Dilutions

• Dilutions:
  • Immunocytochemistry/ Immunofluorescence
  • Western Blot
• Application Notes: Optimal dilution of this antibody should be experimentally determined.

Reactivity Notes

Mammal reactivity reported in scientific literature (PMID:33344730) 94% sequence identity with Rhesus monkey

Packaging, Storage & Formulations

• Storage: Store at 4C in the dark.
• Buffer: 50mM Sodium Borate
• Preservative: 0.05% Sodium Azide
• Purity: Protein G purified

Notes

DyLight (R) is a trademark of Thermo Fisher Scientific Inc. and its subsidiaries.

Alternate Names for CRHR2/CRF2 Antibody [DyLight 405]

• corticotropin releasing hormone receptor 2
• corticotropin-releasing factor receptor 2
• Corticotropin-releasing hormone receptor 2
• CRF2
• CRF2R
• CRFR2
• CRF-R2
• CRF-R-2
• CRFR-2
• CRF-RB
• CRH2R
• CRHR2
• CRH-R2
• CRH-R-2
• HM-CRF

Background

Official Gene Symbol: CRHR2 Gen Bank Accession Number: NP_001874 Gene ID: 1395 (Human) Gene Map Locus: 7p15.1 (Human) CRHR2 is a novel member of Secretin-family-GPCR proteins that functions as a functional receptor for CRF. It is expressed as 3 isoforms; alpha, beta and gamma. These isoforms primarily differ in their N-terminal sequence and tissue distribution. Apart from CRF, other ligands of CRHR2 include UcnI, UcnII and UcnIII. CRHR2 is involved in stress responses, cardiovascular function and gastric motility. Studies on CRHR2 deficient mice suggested a central anxiolytic effect of CRHR2. Northern Blot analysis detects CRHR2 expression in brain, hypothalamus, heart, GI, lung, skeletal muscle and vasculature.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: CRHR2