Copeptin Antibody (579021) [Alexa Fluor® 350]

• Applications: WB
• Clone: 579021
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: Alexa Fluor 350

Copeptin Antibody (579021) [Alexa Fluor® 350] Summary

• Immunogen: Peptide corresponding to the human Copeptin precursor
  Ala126-Gly140
  Accession # P01185
• Specificity: Detects human Copeptin in Western blots.
• Isotype: IgG1
• Clonality: Monoclonal
• Host: Mouse
• Purity Statement: Protein A or G purified

Packaging, Storage & Formulations

• Storage: Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied
• Buffer: Supplied 0.2mg/ml in 1X PBS with RDF1 and 0.09% Sodium Azide

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Background

Copeptin is a 39 amino acid glycosylated peptide that is a proteolytic product derived from a precursor which also contains Vasopressin and Neurophysin 2 peptides. The precursor protein is synthesized and cleaved in the hypothalamus before transport to the pituitary for storage and release. Copeptin is secreted in equimolar amounts with Vasopressin. It is more stable than Vasopressin and serves as a surrogate indicator of Vasopressin release. Vasopressin plays a major role in blood pressure regulation through control of water retention in the kidney and vascular tone. Serum levels of Copeptin are associated with metabolic syndrome, insulin resistance, sepsis, and heart dysfunction following myocardial infarction. Human Copeptin shares 79% sequence identity with mouse and rat Copeptin.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.