CoCoA Antibody

Images

 
Western Blot: CoCoA Antibody [NBP1-32154] - Sample(30 ug of whole cell lysate) A:HeLa S3 7.5% SDS PAGE, antibody diluted at 1:500.
Immunocytochemistry/ Immunofluorescence: CoCoA Antibody [NBP1-32154] - Sample: HeLa cells were fixed in iced-cold MeOH for 5 min. Green: CALCOCO1 protein stained by CoCoA antibody, Internal diluted at 1:500. Blue: ...read more
Immunohistochemistry-Paraffin: CoCoA Antibody [NBP1-32154] - Paraffin-embedded C2C12 xenograft, using antibody at 1:100 dilution.

Product Details

Summary
Reactivity HuSpecies Glossary
Applications WB, ICC/IF, IHC, IHC-P
Clonality
Polyclonal
Host
Rabbit
Conjugate
Unconjugated
Concentration
0.79 mg/ml

Order Details

CoCoA Antibody Summary

Immunogen
Recombinant protein encompassing a sequence within the center region of human CoCoA. The exact sequence is proprietary.
Localization
Cytoplasm, Nucleus
Isotype
IgG
Clonality
Polyclonal
Host
Rabbit
Gene
CALCOCO1
Purity
Immunogen affinity purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Western Blot 1:500-1:3000
  • Immunocytochemistry/Immunofluorescence 1:100-1:1000
  • Immunohistochemistry 10 - 1:500
  • Immunohistochemistry-Paraffin 1:100-1:1000

Packaging, Storage & Formulations

Storage
Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.
Buffer
0.1M Tris (pH 7.0), 0.1M Glycine and 10% Glycerol
Preservative
0.01% Thimerosal
Concentration
0.79 mg/ml
Purity
Immunogen affinity purified

Alternate Names for CoCoA Antibody

  • calcium binding and coiled-coil domain 1
  • calphoglin
  • Cocoa
  • Coiled-coil coactivator protein
  • coiled-coil leucine zipper coactivator 1
  • inorganic pyrophosphatase activator
  • KIAA1536calcium-binding and coiled-coil domain-containing protein 1
  • Sarcoma antigen NY-SAR-3

Background

HPS3 is involved in early stages of melanosome biogenesis and maturation. Defects in HPS3 are the cause of the cocoa (coa) mutant, and of Hermansky-Pudlak syndrome type 3 (HPS3). HPS3 is an autosomal recessive disorder, characterized by oculocutaneous albinism, bleeding due to platelet storage pool deficiency, and lysosomal storage defects. This syndrome results from defects of diverse cytoplasmic organelles including melanosomes, platelet dense granules and lysosomes. Ceroid storage in the lungs is associated with pulmonary fibrosis, a common cause of premature death in individuals with HPS.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Product General Protocols

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Video Protocols

WB Video Protocol
ICC/IF Video Protocol

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Secondary Antibodies

 

Isotype Controls

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Calculators

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Bioinformatics

Gene Symbol CALCOCO1