CNP/NPPC Antibody [Alexa Fluor™ Plus 680]

• Clonality: Polyclonal
• Host: Goat
• Conjugate: Alexa Fluor Plus 680

CNP/NPPC Antibody [Alexa Fluor™ Plus 680] Summary

• Specificity: Detects human CNP in direct ELISAs and Western blots.
• Isotype: IgG
• Clonality: Polyclonal
• Host: Goat

Packaging, Storage & Formulations

• Storage: Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied
• Buffer: Supplied 0.2 mg/mL in a saline solution containing BSA and Sodium Azide.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Background

C-type natriuretic peptide (CNP) belongs to the natriuretic peptide family and functions in an autocrine or paracrine fashion. CNP interacts with the GC-B/NPR-B receptor to promote vasorelaxation, vascular remodeling, and the growth and differentiation of bone and neural tissue. CNP is synthesized as a prohormone that is cleaved intracellularly by furin, yielding a 49 aa propeptide and a 53 aa mature peptide. Additional cleavage of the mature peptide generates 29 aa and 22 aa peptides which have comparable activity in some assays. Within the 103 aa pro CNP, human shares 91% aa sequence identity with mouse and rat pro CNP.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.