CNOT7 Antibody (RB18739)

Product Discontinued

CNOT7 Antibody (RB18739) Summary

• Immunogen: This CAF-1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 34-61 amino acids from the N-terminal region of human CAF-1.
• Isotype: IgG
• Clonality: Polyclonal
• Host: Rabbit
• Gene: CNOT7
• Purity: Protein A purified

Applications/Dilutions

• Dilutions:
  • Immunocytochemistry/ Immunofluorescence 1:10 - 1:50
  • Immunohistochemistry 1:10-1:500
  • Immunohistochemistry-Paraffin 1:50 - 1:100
  • Western Blot 1:1000
• Theoretical MW: 32.745 kDa.
  Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Reactivity Notes

Predicted to react with Bovine, Chicken, Mouse, Xenopus and Zebrafish.

Packaging, Storage & Formulations

• Storage: Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
• Buffer: PBS
• Preservative: 0.09% Sodium Azide
• Concentration: 0.31 mg/ml
• Purity: Protein A purified

Alternate Names for CNOT7 Antibody (RB18739)

• BTG1 binding factor 1
• BTG1-binding factor 1
• CAF-1
• CAF1carbon catabolite repressor protein (CCR4)-associative factor 1
• CCR4-associated factor 1
• CCR4-NOT transcription complex subunit 7
• CCR4-NOT transcription complex, subunit 7
• hCAF-1

Background

The protein encoded by this gene binds to an anti-proliferative protein, B-cell translocation protein 1, which negatively regulates cell proliferation. Binding of the two proteins, which is driven by phosphorylation of the anti-proliferative protein, causes signaling events in cell division that lead to changes in cell proliferation associated with cell-cell contact. The protein has both mouse and yeast orthologs. Alternate splicing of this gene results in two transcript variants encoding different isoforms.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: CNOT7
• Uniprot:
  • Q9UIV1(Human)