CLCN7 Antibody

Immunocytochemistry/Immunofluorescence: CLCN7 Antibody [NBP1-91791] - Immunofluorescent staining of human cell line A549 shows localization to nucleoplasm.

Immunohistochemistry-Paraffin: CLCN7 Antibody [NBP1-91791] - Staining of human duodenum shows strong granular cytoplasmic positivity in glandular cells.

Immunohistochemistry-Paraffin: CLCN7 Antibody [NBP1-91791] - Staining of human testis shows moderate granular cytoplasmic positivity in cells in seminiferous ducts.

Immunohistochemistry-Paraffin: CLCN7 Antibody [NBP1-91791] - Staining of human cerebral cortex shows moderate cytoplasmic positivity in neurons.

Immunohistochemistry-Paraffin: CLCN7 Antibody [NBP1-91791] - Staining of human kidney shows strong granular cytoplasmic positivity in cells in tubules.

Product Discontinued

CLCN7 Antibody Summary

• Immunogen: This antibody was developed against Recombinant Protein corresponding to amino acids: LYDMHIQLQSVPFLHWEAPVTSHSLTAREVMSTPVTCLRRREKVGVIVDVLSDTASNHNGFPVVEHADDTQPARLQGLILRSQLIVLLKHKVFVERS
• Predicted Species: Mouse (96%), Rat (96%). Backed by our 100% Guarantee.
• Isotype: IgG
• Clonality: Polyclonal
• Host: Rabbit
• Gene: CLCN7
• Purity: Immunogen affinity purified

Applications/Dilutions

• Dilutions:
  • Immunocytochemistry/ Immunofluorescence 0.25-2 ug/ml
  • Immunohistochemistry 1:200 - 1:500
  • Immunohistochemistry-Paraffin 1:200 - 1:500
• Application Notes: For IHC-Paraffin, HIER pH 6 retrieval is recommended. ICC/IF Fixation Permeabilization: Use PFA/Triton X-100.

Packaging, Storage & Formulations

• Storage: Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
• Buffer: PBS (pH 7.2) and 40% Glycerol
• Preservative: 0.02% Sodium Azide
• Purity: Immunogen affinity purified

Alternate Names for CLCN7 Antibody

• chloride channel 7
• Chloride channel protein 7
• CLC-7
• CLC7FLJ39644
• FLJ26686
• H(+)/Cl(-) exchange transporter 7
• OPTA2FLJ46423
• OPTB4

Background

The product of this gene belongs to the CLC chloride channel family of proteins. Chloride channels play important roles in the plasma membrane and in intracellular organelles. This gene encodes chloride channel 7. Defects in this gene are the cause of osteopetrosis autosomal recessive type 4 (OPTB4), also called infantile malignant osteopetrosis type 2 as well as the cause of autosomal dominant osteopetrosis type 2 (OPTA2), also called autosomal dominant Albers-Schonberg disease or marble disease autosoml dominant. Osteopetrosis is a rare genetic disease characterized by abnormally dense bone, due to defective resorption of immature bone. OPTA2 is the most common form of osteopetrosis, occurring in adolescence or adulthood.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Publications for CLCN7 Antibody (NBP1-91791)(1)

Publication using NBP1-91791

• Cai Y, Li J, Fan K et al. Downregulation of chloride voltage-gated channel 7 contributes to hyperalgesia following spared nerve injury The Journal of Biological Chemistry 2024-09-12 [PMID: 39276933]

Bioinformatics

• Gene Symbol: CLCN7