CIN85/SH3KBP1 Antibody (931346) [Alexa Fluor® 532]

• Reactivity: Hu
• Applications: ICC/IF
• Clone: 931346
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: Alexa Fluor 532

CIN85/SH3KBP1 Antibody (931346) [Alexa Fluor® 532] Summary

• Immunogen: E. coli-derived recombinant human CIN85/SH3KBP1
  Pro366-Lys665
  Accession # Q96B97
• Specificity: Detects human CIN85/SH3KBP1 in direct ELISAs.
• Source: N/A
• Isotype: IgG1
• Clonality: Monoclonal
• Host: Mouse
• Purity Statement: Protein A or G purified from hybridoma culture supernatant

Applications/Dilutions

• Dilutions:
  • Immunocytochemistry

Packaging, Storage & Formulations

• Storage: Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied
• Buffer: Supplied 0.2 mg/mL in a saline solution containing BSA and Sodium Azide.

Notes

This product is provided under an agreement between Life Technologies Corporation and R&D Systems, Inc, and the manufacture, use, sale or import of this product is subject to one or more US patents and corresponding non-US equivalents, owned by Life Technologies Corporation and its affiliates. The purchase of this product conveys to the buyer the non-transferable right to use the purchased amount of the product and components of the product only in research conducted by the buyer (whether the buyer is an academic or for-profit entity). The sale of this product is expressly conditioned on the buyer not using the product or its components (1) in manufacturing; (2) to provide a service, information, or data to an unaffiliated third party for payment; (3) for therapeutic, diagnostic or prophylactic purposes; (4) to resell, sell, or otherwise transfer this product or its components to any third party, or for any other commercial purpose. Life Technologies Corporation will not assert a claim against the buyer of the infringement of the above patents based on the manufacture, use or sale of a commercial product developed in research by the buyer in which this product or its components was employed, provided that neither this product nor any of its components was used in the manufacture of such product. For information on purchasing a license to this product for purposes other than research, contact Life Technologies Corporation, Cell Analysis Business Unit, Business Development, 29851 Willow Creek Road, Eugene, OR 97402, Tel: (541) 465-8300. Fax: (541) 335-0354.

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for CIN85/SH3KBP1 Antibody (931346) [Alexa Fluor® 532]

• C-Cbl-Interacting Protein
• CD2-binding protein 3
• CD2BP3
• CIN85
• CIN85Cbl-interacting protein of 85 kDa
• GIG10
• HSB1
• HSB-1
• Human Src family kinase-binding protein 1
• MIG18
• migration-inducing gene 18
• SH3 domain-containing kinase-binding protein 1
• SH3-domain kinase binding protein 1
• SH3KBP1
• Src family kinase-binding protein 1
• src-related kinase binding protein-1

Background

Independently identified by several groups, SH3-domain kinase-binding protein 1 (SH3KBP1) is also known as CBL-interacting protein of 85 kDa (CIN85), CD2-binding protein 3 (CD2BP3) and human src family kinase-binding protein 1 (HSB1).  SH3KBP1 is a widely expressed adaptor protein involved in regulating diverse signal transduction pathways, including endocytosis, lysosomal degradation, cell adhesion, stress response, cell morphology and cytoskeletal organization.  The protein contains three N-terminal SH3 domains for complex assembly and a C-terminal coiled coil domain for oligomerization, separated by a proline-rich central region.  Smaller known isoforms of SH3KBP1 lack one or more of the SH3 domains.  Over amino acids (aa) 366-665, human SH3KBP1 shares 92% and 90% aa identity with mouse and rat SH3KBP1, respectively.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Uniprot:
  • Q96B97()