CIDEB Antibody

Western Blot: CIDEB Antibody [NB100-55757] - Used at 2 ug/ml, against 10 ug of mouse liver tissue lysate, to analyze CIDEB.

Product Discontinued

CIDEB Antibody Summary

• Immunogen: The polyclonal antibody was raised against a peptide corresponding to amino acids 204 to 219 of murine CIDEB.
• Specificity: In mouse liver, an approx. 25 kDa band is observed.
• Isotype: IgG
• Clonality: Polyclonal
• Host: Rabbit
• Gene: CIDEB
• Purity: Protein G purified

Applications/Dilutions

• Dilutions:
  • Western Blot
• Control:

  Mouse Liver Whole Tissue Lysate (Adult Whole Normal)

Reactivity Notes

Cross reacts with Mouse.

Packaging, Storage & Formulations

• Storage: Store at 4C. Do not freeze.
• Buffer: PBS
• Preservative: 0.02% Sodium Azide
• Concentration: 0.5 mg/ml
• Purity: Protein G purified

Alternate Names for CIDEB Antibody

• cell death-inducing DFFA-like effector bcell death activator CIDE-B

Background

Apoptosis is related to many diseases and induced by a family of cell death receptors and their ligands. Cell death signals are transduced by death domain containing adapter molecules and members of the caspase family of proteases. These death signals finally cause the degradation of chromosomal DNA by activated DNase. DFF45/ICAD has been identified as inhibitor of caspase activated DNase DFF40/CAD. DFF45 related proteins CIDEA and CIDEB (for cell death-inducing DFF-like effector A and B) were recently identified (2). CIDE contains a new type of domain termed CIDEN, which has high homology with the regulatory domains of DFF45/ICAD and DFF/CAD (1,2). Expression of CIDEB induces apoptosis, which is inhibited by DFF45. CIDEB is expressed mainly in liver and at lower levels in spleen, kidney, peripheral blood lymphocytes, and bone marrow (2).

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: CIDEB