Cerebellin-4 Antibody [Alexa Fluor® 647]

• Reactivity: Hu
• Applications: IHC
• Clonality: Polyclonal
• Host: Sheep
• Conjugate: Alexa Fluor 647

Cerebellin-4 Antibody [Alexa Fluor® 647] Summary

• Immunogen: Chinese hamster ovary cell line CHO-derived recombinant human Cerebellin-4
  Gln28-Leu201
  Accession # Q9NTU7
• Specificity: Detects human Cerebellin-4 in direct ELISAs. In direct ELISAs, approximately 10% cross-reactivity with recombinant human (rh) Cerebellin-1 is observed, and less than 5% cross-reactivity with rhCerebellin-2 and rhCerebellin-3 is observed.
• Isotype: IgG
• Clonality: Polyclonal
• Host: Sheep
• Purity Statement: Antigen Affinity-purified

Applications/Dilutions

• Dilutions:
  • Immunohistochemistry

Packaging, Storage & Formulations

• Storage: Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied
• Buffer: Supplied 0.2mg/ml in 1X PBS with RDF1 and 0.09% Sodium Azide

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Cerebellin-4 Antibody [Alexa Fluor® 647]

• CBLN4
• CBLNL1
• cerebellin 4 precursor
• cerebellin precursor-like 1
• Cerebellin4
• Cerebellin-4
• Cerebellin-like glycoprotein 1
• dJ885A10.1

Background

CBLN4 (Cerebellin-4) is a 26-35 kDa, secreted glycoprotein member of the C1q/TNF Superfamily of molecules. It is expressed in developing Sertoli cells and select neurons in the dorsal raphe, entorhinal cortex and arcuate nucleus. In the testis, it likely promotes cell differentiation; in the brain, it is possible that it participates in synapse formation via an interaction with neurexin. Mature human CBLN4 is 174 amino acids (aa) in length (aa 28-201). It contains two N-terminal cysteines that mediate homohexamer formation, and a C-terminal C1q domain (aa 66-201) that promotes homotrimer formation. CBLN4 also reportedly has the potential to multimerize with the other CBLN-related molecules, CBLN1-3. Mature human CBLN4 shares 99% aa identity with mouse CBLN4.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.