CDR2 Antibody (33)

Images

 
Western Blot: CDR2 Antibody (33) [NBP2-10509] - Western blot analysis of CDR2 expression in 1) HeLa control cell lysate and 2) HeLa cell lysate overexpressing CDR2.
Immunohistochemistry: CDR2 Antibody (33) [NBP2-10509] - IHC staining of CDR2 in human breast cancer using DAB with hematoxylin counterstain.
Western Blot: CDR2 Antibody (33) [NBP2-10509] - Western blot analysis of CDR2 expression in 1) HeLa, 2) NTERA-2 and 3) HepG2 whole cell lysates.

Product Details

Summary
Reactivity Hu, Mu(-)Species Glossary
Applications WB, ELISA, IHC, IHC-P, IP
Clone
33
Clonality
Monoclonal
Host
Mouse
Conjugate
Unconjugated
Concentration
1.0 mg/ml

Order Details

CDR2 Antibody (33) Summary

Immunogen
N-terminal MBP-tagged full length human CDR2 [Swiss-Prot # Q01850]
Specificity
Does not cross react with mouse Cdr2 and human Cdr3.
Isotype
IgG1
Clonality
Monoclonal
Host
Mouse
Gene
CDR2
Purity
Protein G purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Western Blot 1:500-1:1000
  • ELISA 1:100-1:2000
  • Immunohistochemistry 1:50-1:100
  • Immunohistochemistry-Paraffin 1:50-1:100
  • Immunoprecipitation 1:10-1:100
Application Notes
This CDR2 Antibody (33) is useful for Western blot, Immunoprecipitation, Immunohistochemistry on paraffin-embedded sections and ELISA. In Western blot, a single or double band can be seen around 55 kDa representing CDR2. In IHC-P, heavy nuclear staining was observed with some cytoplasmic signal in human breast cancer. Prior to immunostaining paraffin tissues, antigen retrieval with sodium citrate buffer (pH 6.0) is recommended.
Control
HeLa Whole Cell Lysate
HepG2 Whole Cell Lysate
NTERA-2 Whole Cell Lysate
Publications
Read Publication using
NBP2-10509 in the following applications:

  • IHC
    1 publication
  • WB
    1 publication

Reactivity Notes

Human. Does not react with mouse.

Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
Tris-Glycine (pH 7.5) and 0.15M NaCl
Preservative
0.05% Sodium Azide
Concentration
1.0 mg/ml
Purity
Protein G purified

Alternate Names for CDR2 Antibody (33)

  • CDR62
  • cerebellar degeneration-related protein (62kD)
  • cerebellar degeneration-related protein 2
  • cerebellar degeneration-related protein 2, 62kDa
  • Major Yo paraneoplastic antigen
  • Paraneoplastic cerebellar degeneration-associated antigen
  • PCD17
  • Yo paraneoplastic antigen
  • Yo

Background

CDR2, also known as cerebellar degeneration-related protein 2 and Yo, is a tumor antigen which has been linked to a rare disorder known as Paraneoplastic cerebellar degeneration (PCD). CDR2 is expressed in a high percentage of ovary and breast tumors and has been shown as the target antigen of a naturally occurring tumor immune response in PCD patients. Additionally, a connection has been reported between CDR2 and attenuation of tumor hypoxia signaling in the papillary subtype of renal cell carcinoma (Balamurugan K et al., 2009).

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Applications: WB, ELISA, IHC, IHC-P, IP

Publications for CDR2 Antibody (NBP2-10509)(1)

We have publications tested in 1 confirmed species: Human.

We have publications tested in 2 applications: IHC, WB.


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IHC
(1)
WB
(1)
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Filter By Species
Human
(1)
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Product General Protocols

View specific protocols for CDR2 Antibody (NBP2-10509): Find general support by application which include: protocols, troubleshooting, illustrated assays, videos and webinars.

Video Protocols

WB Video Protocol

FAQs for CDR2 Antibody (NBP2-10509). (Showing 1 - 1 of 1 FAQ).

  1. I'm looking for an antibody against human CDR2 to recognize thymic epithelial cells. You have several anti CDR2 antibodies. Are they against a thymic epithelial antigen or against the cerebellar degeneration-related protein 2, 62kDa?
    • Yes, the specific antibody you have inquired about is against cerebellar degeneration-related protein 2, 62 kDa. Moreover, all of our CDR2 primaries are against the same target.

Control Lysate(s)

Secondary Antibodies

 

Isotype Controls

Other Available Formats

Alexa Fluor 350 NBP2-10509AF350
Alexa Fluor 405 NBP2-10509AF405
Alexa Fluor 488 NBP2-10509AF488
Alexa Fluor 532 NBP2-10509AF532
Alexa Fluor 594 NBP2-10509AF594
Alexa Fluor 647 NBP2-10509AF647
Alexa Fluor 700 NBP2-10509AF700
Alexa Fluor 750 NBP2-10509AF750
Biotin NBP2-10509B
DyLight 350 NBP2-10509UV
DyLight 405 NBP2-10509V
DyLight 488 NBP2-10509G
DyLight 550 NBP2-10509R
DyLight 594 NBP2-10509DL594
DyLight 650 NBP2-10509C
DyLight 680 NBP2-10509FR
DyLight 755 NBP2-10509IR
FITC NBP2-10509F
HRP NBP2-10509H
Janelia Fluor 549 NBP2-10509JF549
Janelia Fluor 646 NBP2-10509JF646

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Blogs on CDR2.

Cerebellar Degeneration-Related Protein 2 (CDR2): Cell-Cycle Regulated Tumor Antigen
CDR2 is a tumor antigen expressed in a high percentage of breast and ovarian tumors and is the target of a naturally occurring tumor immune response in patients with paraneoplastic cerebellar degeneration. CDR2 has also been shown to be a cell cycle r...  Read full blog post.

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Bioinformatics

Gene Symbol CDR2
Entrez
Uniprot