CD79A Antibody (706931) [Phycoerythrin]

Human peripheral blood lymphocytes were stained with Mouse Anti-Human CD19 APC-conjugated Monoclonal Antibody (Catalog # FAB4867A) and either (A) Mouse Anti-Human CD79A PE-conjugated Monoclonal Antibody (Catalog # FAB69201P) or (B) Mouse IgG1Phycoerythrin Isotype Control (Catalog # IC002P). View our protocol for Staining Membrane-associated Proteins.

• Reactivity: Hu
• Applications: Flow
• Clone: 706931
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: Phycoerythrin

CD79A Antibody (706931) [Phycoerythrin] Summary

• Immunogen: Mouse myeloma cell line NS0-derived recombinant human CD79A
  Leu33-Arg143
  Accession # P11912
• Specificity: Detects human CD79A in direct ELISAs. In direct ELISAs, no cross-reactivity with recombinant mouse CD79A is observed.
• Source: N/A
• Isotype: IgG1
• Clonality: Monoclonal
• Host: Mouse
• Gene: CD79A
• Purity Statement: Protein A or G purified from hybridoma culture supernatant

Applications/Dilutions

• Dilutions:
  • Flow Cytometry 10 uL/10^6 cells

Packaging, Storage & Formulations

• Storage: Protect from light. Do not freeze.
  • 12 months from date of receipt, 2 to 8 °C as supplied.
• Buffer: Supplied in a saline solution containing BSA and Sodium Azide.
• Preservative: Sodium Azide

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for CD79A Antibody (706931) [Phycoerythrin]

• CD79A antigen (immunoglobulin-associated alpha)
• CD79a antigen
• CD79a molecule, immunoglobulin-associated alpha
• CD79A
• IGAB-cell antigen receptor complex-associated protein alpha chain
• ig-alpha
• MB-1 membrane glycoprotein
• MB1
• MB-1
• Membrane-bound immunoglobulin-associated protein
• Surface IgM-associated protein

Background

CD79A, also known as Ig alpha and MB-1, is a 44 kDa transmembrane glycoprotein in the immunoglobulin superfamily. It contains a single Ig-like domain in its extracellular region (ECD) and one cytoplasmic immunoreceptor tyrosine-based activation motif (ITAM). Alternate splicing generates a short isoform with a 39 aa deletion in the ECD. Heterodimers of CD79A and CD79B/Ig beta associate with a membrane bound immunoglobulin on the B cell surface to form the B cell Antigen Receptor Complex (BCR). CD79A and CD79B are required for BCR-mediated signaling and consequently for the development and activation of B lineage cells. Within the ECD, human CD79A shares 57% aa sequence identity with mouse and rat CD79A.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Publications for CD79A Antibody (FAB69201P)(3)

Publications using FAB69201P

• Iris A. Otto, Paulina Nuñez Bernal, Margot Rikkers, Mattie H.P. van Rijen, Anneloes Mensinga, Moshe Kon et al. Human adult, pediatric and microtia auricular cartilage harbor fibronectin-adhering progenitor cells with regenerative ear reconstruction potential iScience 2022-09-16 [PMID: 36105583]
• Scott M. Wemlinger, Chelsea R. Parker Parker Harp, Bo Yu, Ian R. Hardy, Matthew Seefeldt, Jennifer Matsuda et al. Preclinical Analysis of Candidate Anti-Human CD79 Therapeutic Antibodies Using a Humanized CD79 Mouse Model The Journal of Immunology 2022-04-01 [PMID: 35321883]
• Scott M. Wemlinger, Chelsea R. Parker Parker Harp, Bo Yu, Ian R. Hardy, Matthew Seefeldt, Jennifer Matsuda et al. Preclinical Analysis of Candidate Anti-Human CD79 Therapeutic Antibodies Using a Humanized CD79 Mouse Model The Journal of Immunology 2022-04-01 [PMID: 35321883] (Immunocytochemistry, Mouse, Transgenic Mouse)

Bioinformatics

• Gene Symbol: CD79A
• Uniprot:
  • P11912()