Recombinant Human CD23/Fc epsilon RII Protein

Product Discontinued

Recombinant Human CD23/Fc epsilon RII Protein Summary

• Description: A recombinant protein with a C-Terminal His-tag and corresponding to the amino acids 48-321 of Human CD23/Fc epsilon RII
  
  

  Source:Baculovirus

  Amino Acid Sequence: ADPDTTQSLK QLEERAARNV SQVSKNLESH HGDQMAQKSQ STQISQELEE LRAEQQRLKS QDLELSWNLN GLQADLSSFK SQELNERNEA SDLLERLREE VTKLRMELQV SSGFVCNTCP EKWINFQRKC YYFGKGTKQW VHARYACDDM EGQLVSIHSP EEQDFLTKHA SHTGSWIGLR NLDLKGEFIW VDGSHVDYSN WAPGEPTSRS QGEDCVMMRG SGRWNDAFCD RKLGAWVCDR LATCTPPASE GSAESMGPDS RPDPDGRLPT PSAPLHSHHH HHH

• Source: Baculovirus
• Protein/Peptide Type: Recombinant Protein
• Gene: FCER2
• Purity: >90%, by SDS-PAGE
• Endotoxin Note: < 1.0 EU per 1ug of protein (determined by LAL method)

Applications/Dilutions

• Dilutions:
  • SDS-Page
• Theoretical MW: 32 kDa.
  Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Packaging, Storage & Formulations

• Storage: Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
• Buffer: PBS (pH 7.4), 10% glycerol
• Preservative: No Preservative
• Concentration: 0.25 mg/ml
• Purity: >90%, by SDS-PAGE

Alternate Names for Recombinant Human CD23/Fc epsilon RII Protein

• BLAST-2
• CD23
• CD23A
• CD23CD23 antigen
• CLEC4J
• CLEC4JC-type lectin domain family 4 member J
• C-type lectin domain family 4, member J
• Fc epsilon RII
• Fc fragment of IgE, low affinity II, receptor for (CD23)
• FCE2Fc fragment of IgE, low affinity II, receptor for (CD23A)
• fc-epsilon-RII
• FCER2
• Fcer2a
• FceRII
• IGEBF
• Immunoglobulin E-binding factor
• low affinity immunoglobulin epsilon Fc receptor
• Ly-42
• Lymphocyte IgE receptor

Background

The CD23 antigen is the low affinity IgE Fc receptor, which is a 49 kDa protein with 38 and 28 kDa fragments. It is expressed on most mature, conventional B cells (but not on peritoneal CD5+ B cells), and can also be found on the surface of T cells, macrophages, platelets and EBV transformed B lymphoblasts. Expression of CD23 has been detected in neoplastic cells from cases of B cell chronic Lymphocytic leukemia. CD23 is expressed by B cells in the follicular mantle but not by proliferating germinal centre cells. CD23 is also expressed by eosinophils. CD23 is distinct from the high affinity IgE receptors found on basophils and mast cells, which mediate allergic reactions. The low affinity receptors are thought to play a role in isotype specific immunoregulation. The regulation of CD23 surface expression appears to be integral with the complex IgE system, which involves interactions of cells, cytokines, antibodies and regulatory factors. CD23 has been described as a

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Peptides and proteins are guaranteed for 3 months from date of receipt.

Bioinformatics

• Gene Symbol: FCER2