CD23/Fc epsilon RII Products

Description

The CD23 antigen is the low affinity IgE Fc receptor, which is a 49 kDa protein with 38 and 28 kDa fragments. It is expressed on most mature, conventional B cells (but not on peritoneal CD5+ B cells), and can also be found on the surface of T cells, macrophages, platelets and EBV transformed B lymphoblasts. Expression of CD23 has been detected in neoplastic cells from cases of B cell chronic Lymphocytic leukemia. CD23 is expressed by B cells in the follicular mantle but not by proliferating germinal centre cells. CD23 is also expressed by eosinophils. CD23 is distinct from the high affinity IgE receptors found on basophils and mast cells, which mediate allergic reactions. The low affinity receptors are thought to play a role in isotype specific immunoregulation. The regulation of CD23 surface expression appears to be integral with the complex IgE system, which involves interactions of cells, cytokines, antibodies and regulatory factors. CD23 has been described as a

Bioinformatics

Entrez	14127 Mouse 2208 Human
Uniprot	AAH14108 Human NM_002002 Human NP_001993.2 Human P06734 Human
Product By Gene ID	2208
Alternate Names	BLAST-2 CD23A CD23CD23 antigen CLEC4JC-type lectin domain family 4 member J C-type lectin domain family 4, member J Fc fragment of IgE, low affinity II, receptor for (CD23) FCE2Fc fragment of IgE, low affinity II, receptor for (CD23A) Fc-epsilon-RII fc-epsilon-RII IGEBF Immunoglobulin E-binding factor low affinity immunoglobulin epsilon Fc receptor Lymphocyte IgE receptor

Research Areas for CD23/Fc epsilon RII

Find related products by research area and learn more about each of the different research areas below.

Adaptive Immunity
Cancer
Immunology
Phospho-Specific