CD23/Fc epsilon RII Antibody (5B5) Summary
Purified recombinant fragment of human FCER2 expressed in E. Coli.
Test in a species/application not listed above to receive a full credit towards a future purchase.
Packaging, Storage & Formulations
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Ascitic fluid containing 0.03% sodium azide.
0.03% Sodium Azide
- Western Blot 1:500-1:2000
- ELISA 1:10000
- Flow Cytometry
- Immunocytochemistry/Immunofluorescence 1:200-1:1000
Alternate Names for CD23/Fc epsilon RII Antibody (5B5)
- CD23CD23 antigen
- CLEC4JC-type lectin domain family 4 member J
- C-type lectin domain family 4, member J
- Fc epsilon RII
- Fc fragment of IgE, low affinity II, receptor for (CD23)
- FCE2Fc fragment of IgE, low affinity II, receptor for (CD23A)
- Immunoglobulin E-binding factor
- low affinity immunoglobulin epsilon Fc receptor
- Lymphocyte IgE receptor
CD23 is a 45 kD protein, also known as Leu-20, FcepsilonRII, IgE Fc receptor, BLAST-2, B6, and low affinity IgE receptor. It is a member of the Ig family, expressed on most mature B cells, B cells in follicular mantle (but not in proliferating germinal center cells, follicular dendritic cells, monocytes, eosinophils, Langerhans cells, and a subset of T cells (10-15% of tonsillar T cells). CD23 responds to high levels of IgE by downregulating IgE secretion. In human monocytes, CD23 triggering results in release of pro-inflammatory cytokines including TNF-alpha, IL-1, IL-6, and GM-CSF. CD23 can be proteolytically cleaved to generate soluble CD23 fragments of various molecular weights. In chronic lymphocytic leukemia, levels of soluble CD23 in the serum can be used as a prognostic marker to identify patients at high risk for disease progression. Alternate splicing of exon 2 can also generate two cell-surface isoforms of CD23 differing by 6 amino acids in their cytoplasmic region. The D3.6 antibody against human CD23 has been shown to be useful for flow cytometry.
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed
for 1 year from date of receipt.
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