CD155/PVR Antibody (300903) [Unconjugated]

Images

 
Western blot shows lysates of human heart tissue, HT1080 human fibrosarcoma cell line, and HUVEC human umbilical vein endothelial cells. PVDF membrane was probed with 1 µg/mL of Mouse Anti-Human CD155/PVR ...read more

Product Details

Summary
Reactivity HuSpecies Glossary
Applications WB
Clone
300903
Clonality
Monoclonal
Host
Mouse
Conjugate
Unconjugated
Concentration
LYOPH

Order Details

View Available Formulations
Catalog# & Formulation Size Price

CD155/PVR Antibody (300903) [Unconjugated] Summary

Immunogen
Mouse myeloma cell line NS0-derived recombinant human CD155/PVR
Gly27-Asn343
Accession # ABM85069
Specificity
Detects human CD155/PVR in direct ELISAs and Western blots.
Source
N/A
Isotype
IgG1
Clonality
Monoclonal
Host
Mouse
Gene
PVR
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Western Blot 1 ug/mL
Control
CD155/PVR Knockout 293T Cell Lysate
Publications
Read Publication using
MAB2530 in the following applications:

Packaging, Storage & Formulations

Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Buffer
Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied as a 0.2 µm filtered solution in PBS.
Preservative
No Preservative
Concentration
LYOPH
Reconstitution Instructions
Reconstitute at 0.5 mg/mL in sterile PBS.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for CD155/PVR Antibody (300903) [Unconjugated]

  • CD155 antigen
  • CD155
  • HVED
  • NECL5
  • Necl-5
  • nectin-like 5
  • Nectin-like protein 5
  • poliovirus receptor
  • PVR
  • PVS
  • PVSFLJ25946
  • Tage4

Background

CD155 [also known as PVR (poliovirus receptor) and Necl-5 (nectin-like molecule-5)] is a 70 kDa type I transmembrane (TM) glycoprotein that is a member of the nectin-like (Necl) family of nectin-related molecules (1). Like nectins, Necl molecules are Ig superfamily members that contain three Ig-like extracellular domains, a TM segment, and a cytoplasmic tail. Unlike nectins, Necl molecules cannot interact with cytoplasmic afadin (1). While Nectins serve as cell adhesion molecules, the actual functions of most Necls are yet-to-be determined. CD155/PVR was originally isolated based on its ability to mediate polio virus attachment to host cells (2, 3). The full-length (or CD155 alpha isoform) is synthesized as a 417 amino acid (aa) precursor that contains a 20 aa signal sequence, a 323 aa extracellular region, a 24 aa TM segment and a 50 aa cytoplasmic tail. The extracellular region contains one N-terminal V-type and two C2-type Ig-like domains (2, 3). The V-type domain mediates polio virus binding (4). Three other isoforms exist, all of which retain the Ig-like domains. CD155δ is transmembrane with a shortened cytoplasmic tail of 25 aa. CD155 beta (352 aa) and CD155 gamma (344 aa) are 60‑65 kDa soluble forms that show removal of the TM segment and surrounding amino acids (2, 5). The soluble forms will bind the polio virus (due to the presence of the V-type Ig domain) but afford no protection against polio infection because of low circulating levels (5). CD155 has been demonstrated to bind vitronectin, nectin-3, and DNAM-1 (6‑8). DNAM-1 binding promotes monocyte migration and NK cell killing. CD155 is expressed in all normal tissues and is highly expressed in tumor cells of epithelial and neuronal origin.

  1. Takai, Y. et al. (2003) Cancer Sci. 94:655.
  2. Mendelsohn, C.L. et al. (1989) Cell 56:855.
  3. Koike, H. et al. (1990) EMBO J. 9:3217.
  4. Koike, S. et al. (1991) Proc. Natl. Acad. Sci. USA 88:4104.
  5. Baury, B. et al. (2003) Biochem. Biophys. Res. Commun. 309:175.
  6. Mueller, S. and E. Wimmer (2003) J. Biol. Chem. 278:31251.
  7. Reymond, N. et al. (2004) J. Exp. Med. 199:1331.
  8. Lange, R. et al. (2001) Virology 285:218.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Customers Who Viewed This Item Also Viewed...

AF6240
Species: Hu
Applications: WB, ELISA, IHC
NBP2-24614
Species: Hu, Mu, Rt, Op, Pm
Applications: WB
NBP2-24763
Species: Hu, Pm
Applications: WB, IHC, IHC-P
NBP1-87345
Species: Hu
Applications: ICC/IF, IHC, IHC-P
NBP1-87343
Species: Hu, Rt
Applications: WB, IHC, IHC-P
NBP2-24643
Species: Mu, Rt
Applications: WB
NBP1-86794
Species: Hu
Applications: WB, ICC/IF
NBP1-55238
Species: Hu, Mu, Rt, Bv, Ca, Eq, GP, Rb, Ze
Applications: WB
NBP2-77357
Species: Hu
Applications: WB, IHC, IHC-P, IP, ICC
NBP1-92172
Species: Hu
Applications: WB, ICC/IF, IHC, IHC-P
AF2229
Species: Hu
Applications: WB, Simple Western, IHC, ICC
H00005555-P01
Species: Hu
NBP1-56853
Species: Hu, Mu, Rt, Po, Bv, Ca, Eq, GP, Rb, Ze
Applications: WB, ICC/IF, IHC
NBP2-01763
Species: Hu, Mu
Applications: WB, Flow, IHC, IHC-P
NBP1-47659
Species: Hu
Applications: WB, IHC, IHC-P
NBP2-23368
Species: Hu
H00002038-M01
Species: Hu
Applications: WB, ELISA, ICC/IF
MAB2530
Species: Hu
Applications: WB

Publications for CD155/PVR Antibody (MAB2530)(1)

We have publications tested in 1 confirmed species: Human.

We have publications tested in 1 application: Western Blot.


Filter By Application
Western Blot
(1)
All Applications
Filter By Species
Human
(1)
All Species

Reviews for CD155/PVR Antibody (MAB2530) (0)

There are no reviews for CD155/PVR Antibody (MAB2530). By submitting a review you will receive an Amazon e-Gift Card or Novus Product Discount.
  • Review with no image -- $10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen
  • Review with an image -- $25/€18/£15/$25 CAD/¥150 Yuan/¥2500 Yen

Product General Protocols

Find general support by application which include: protocols, troubleshooting, illustrated assays, videos and webinars.

Video Protocols

WB Video Protocol

FAQs for CD155/PVR Antibody (MAB2530) (0)

There are no specific FAQs related to this product. Read our general customer & technical service FAQs.

Control Lysate(s)

Secondary Antibodies

 

Isotype Controls

Other Available Formats

Additional CD155/PVR Products

Bioinformatics Tool for CD155/PVR Antibody (MAB2530)

Discover related pathways, diseases and genes to CD155/PVR Antibody (MAB2530). Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
Visit Tool

Diseases for CD155/PVR Antibody (MAB2530)

Discover more about diseases related to CD155/PVR Antibody (MAB2530).
 

Pathways for CD155/PVR Antibody (MAB2530)

View related products by pathway.

PTMs for CD155/PVR Antibody (MAB2530)

Learn more about PTMs related to CD155/PVR Antibody (MAB2530).

Blogs on CD155/PVR

There are no specific blogs for CD155/PVR, but you can read our latest blog posts.
Recombinant Monoclonal Antibodies

Customers Who Bought This Also Bought

Contact Information

Product PDFs

Calculators

Concentration Calculator

The concentration calculator allows you to quickly calculate the volume, mass or concentration of your vial. Simply enter your mass, volume, or concentration values for your reagent and the calculator will determine the rest.

=
÷

Review this Product

Be the first to review our CD155/PVR Antibody (300903) [Unconjugated] and receive a gift card or discount.

Bioinformatics

Gene Symbol PVR
Uniprot