Caspr1 Antibody (753232) [Alexa Fluor® 647]

• Reactivity: Hu
• Applications: ICC/IF
• Clone: 753232
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: Alexa Fluor 647

Caspr1 Antibody (753232) [Alexa Fluor® 647] Summary

• Immunogen: Chinese hamster ovary cell line CHO-derived recombinant human Caspr1
  Trp20-Gly1280
  Accession # P78357
• Specificity: Detects human Caspr1 in direct ELISAs. In direct ELISAs, no cross-reactivity with recombinant human Caspr2 is observed.
• Isotype: IgG2a
• Clonality: Monoclonal
• Host: Mouse
• Purity Statement: Protein A or G purified

Applications/Dilutions

• Dilutions:
  • Immunocytochemistry

Packaging, Storage & Formulations

• Storage: Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied
• Buffer: Supplied 0.2mg/ml in 1X PBS with RDF1 and 0.09% Sodium Azide

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Caspr1 Antibody (753232) [Alexa Fluor® 647]

• Caspr
• Caspr1
• CASPRcaspr1
• CNTNAP
• CNTNAP1
• contactin associated protein 1
• neurexin 4
• Neurexin IV
• neurexin-4
• NRXN4contactin-associated protein 1
• p190

Background

Contactin-associated protein 1 (Caspr1), also known as Neurexin-4, Paranodin, and NCP1, is an approximately 190 kDa transmembrane protein that is concentrated at paranodal junctions of axons during myelination. It is required for junction formation and ion channel localization and plays an important role in the propagation of saltatory nerve conduction. Caspr1 interacts with Contactins and Nogo-A at the paranodal junction and inhibits the binding of Contactin to glial cell Neurofascin. Caspr1 is proteolytically cleaved by Reelin, and this action is inhibited by the cellular prion protein (PrP). Mature human Caspr1 consists of a 1264 amino acid (aa) extracellular domain (ECD), a 21 aa transmembrane segment, and an 80 aa cytoplasmic domain. The ECD contains one Factor 5/8-like domain, four Laminin-G-like domains, two EGF-like domains, and one Fibrinogen-like domain. Within the ECD, human Caspr1 shares 95% aa sequence identity with mouse and rat Caspr1.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.