Caspase-12 Antibody


Western Blot: Caspase-12 Antibody [NBP1-77290] - Analysis of caspase-12 in (A) human and (B) mouse spleen tissue lysates with caspase-12 antibody at 1 ug/mL.
Immunohistochemistry: Caspase-12 Antibody [NBP1-77290] - Caspase-12 in human heart tissue with caspase-12 antibody at 10 ug/mL.
Western Blot: Caspase-12 Antibody [NBP1-77290] - Human (A) and mouse (B) spleen tissue lysates with caspase-12 antibody at 1 ug/ml.

Product Details

Reactivity Hu, Mu, RtSpecies Glossary
Applications WB, ELISA, IHC, IHC-P
1 mg/ml

Order Details

Caspase-12 Antibody Summary

Antibody was raised against a peptide corresponding to amino acids 2 to 17 of murine caspase-12.
Immunogen affinity purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Packaging, Storage & Formulations

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
0.02% Sodium Azide
1 mg/ml
Immunogen affinity purified


Application Notes
Caspase-12 antibody can be used for detection of caspase-12 by Western blot at 0.5 to 1 mg/ml.
Control Peptide
Caspase-12 Peptide (NBP1-77290PEP)

Reactivity Notes

Human, Mouse, Rat

Alternate Names for Caspase-12 Antibody

  • Apoptosis Related Cysteine Protease
  • CASP 12
  • CASP12
  • CASP12P1
  • Caspase 12 pseudogene 1
  • Caspase12
  • UNQ9415


Three distinct signaling pathways lead to programmed cell death (apoptosis). The death receptor and mitochondrion pathways are the mains, in which the key apoptotic proteases capase-8 and caspase-9, respectively, are involved. The endoplasmic reticulum (ER) stress is the third apoptotic pathway and caspase-12 is involved. Caspase-12 is localized to the ER but not to cytoplasm or mitochondrion. Caspase-12 is activated by ER stress, including disruption of ER calcium homeostasis, and mediates ER stress-induced apoptosis. Caspase-12 is co-localized to the ER with several proteins that are involved in Alzheimer's disease including gamma-secretase presenilin and beta-amyloid precursor protein (APP). Caspase-12 mediates cytotoxicity induced by amyloid-beta. Caspase-12 is ubiquitously expressed in mouse tissues.


This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Customers Who Viewed This Item Also Viewed...

Species: Hu, Mu, Rt
Applications: WB, ELISA, ICC/IF, IHC, IHC-P
Species: Hu, Mu, Rt, Po, ChHa, Ma
Applications: WB, Simple Western, EM, Flow, ICC/IF, IHC, IHC-Fr, IHC-P
Species: Hu, Mu, Rt, Ch, Sh
Applications: WB, Simple Western, Flow, ICC/IF
Species: Hu, Mu, Rt, Pm
Applications: WB, Simple Western, GS, ICC/IF, IHC, IHC-P, IP
Species: Hu, Mu, Rt, Ca, Ge
Applications: IHC, IHC-Fr, IHC-P, IP, Flow-IC
Species: Hu, Mu, Rt, Po, Ca, Dr, Eq, Ma, Rb
Applications: WB, Flow, ICC/IF, IHC, IHC-P
Species: Hu, Mu, Rt, Ge
Applications: WB, IHC, IHC-Fr, IHC-P, IP
Species: Hu, Mu, Rt, Ge
Applications: WB, ICC/IF, IHC, IHC-Fr, IHC-P, IP
Species: Hu, Mu
Applications: WB, Simple Western, IP
Species: Hu, Mu, Rt, Ge
Applications: WB, ICC/IF, IHC, IHC-Fr, IHC-P, IP
Species: Hu, Mu, Rt
Applications: WB
Species: Hu, Mu, Rt, Fi, Ha, Rb
Applications: WB, ChIP, Flow, ICC/IF, IHC, IHC-Fr, IHC-P, IP
Species: Hu, Mu, Ca
Applications: WB, IHC, IHC-P, IP

Publications for Caspase-12 Antibody (NBP1-77290) (0)

There are no publications for Caspase-12 Antibody (NBP1-77290).
By submitting your publication information earn gift cards and discounts for future purchases.

Reviews for Caspase-12 Antibody (NBP1-77290) (0)

There are no reviews for Caspase-12 Antibody (NBP1-77290). By submitting a review earn points towards our Rewards Program.
  • 250 points for product review
  • 500 additional points for an image with your product review
  • Double points (500) if you are the first to review this product
  • Double points (1000) if you are the first to review this product with an image

Product General Protocols

Find general support by application which include: protocols, troubleshooting, illustrated assays, videos and webinars.

Video Protocols

WB Video Protocol

FAQs for Caspase-12 Antibody (NBP1-77290) (0)

There are no specific FAQs related to this product. Read our general customer & technical service FAQs.

Secondary Antibodies


Isotype Controls

Additional Caspase-12 Antibody Products

Related Products by Gene

Bioinformatics Tool for Caspase-12 Antibody (NBP1-77290)

Discover related pathways, diseases and genes to Caspase-12 Antibody (NBP1-77290). Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
Visit Tool

Diseases for Caspase-12 Antibody (NBP1-77290)

Discover more about diseases related to Caspase-12 Antibody (NBP1-77290).

Pathways for Caspase-12 Antibody (NBP1-77290)

View related products by pathway.

PTMs for Caspase-12 Antibody (NBP1-77290)

Learn more about PTMs related to Caspase-12 Antibody (NBP1-77290).

Research Areas for Caspase-12 Antibody (NBP1-77290)

Find related products by research area.

Blogs on Caspase-12.

Caspase-12 - activator of apoptosis via the ER stress response
Aside from their important role in apoptosis, caspases also play an important role in inflammatory processes. Humans express four inflammatory caspases: Caspase-1, -4, -5, and -12. Caspase-12 is a 48 kDa protein localized to the ER and involved in...  Read full blog post.

Contact Information

Product PDFs


Gene Symbol CASP12

Customer Resources

Novus Review - Submit your review and earn rewards points which can be used for merchandise & discounts.
Risk Free Testing - Test on a species/application not listed above to receive a full credit towards a future purchase.

Novus' Quality Guarantee - Novus guarantees that every product we sell will work in the application and species listed on our website and datasheets.

Submit your question on NBP1-77290 below.
During business hours, we will respond to your email within 24 hours. For any questions submitted on the weekend, a response will be received on Monday.
For immediate assistance during business hours M- F (excluding major holidays), please contact us.
Ask a Scientist - We have a lab full of white coats just waiting for your scientific questions and concerns.

Customers Who Bought This Also Bought