Caspase-12 Products

Antibodies
Caspase-12 Antibody
Caspase-12 Antibody
NBP1-76801
Species: Hu, Mu, Rt
Applications: WB, ELISA, ICC/IF, IHC, IHC-P
Host: Rabbit Polyclonal
Caspase-12 Antibody
Caspase-12 Antibody
Species: Hu, Mu, Rt
Applications: WB, ELISA, ICC/IF, IHC, IHC-P, IF
Host: Rabbit Polyclonal
Caspase-12 Antibody
Caspase-12 Antibody
NBP2-24618
Species: Hu
Applications: WB
Host: Rabbit Polyclonal
Kits
Caspase-12 Fluorometric Assay ...
Caspase-12 Fluorometric Assay Kit
NBP2-54840
Species: Hu, Mu, Rt, Ma
Caspase-12 Fluorometric Assay ...
Caspase-12 Fluorometric Assay Kit
KA0734
Species: Ma
Applications: Flow, Func
Caspase-12 Fluorometric Assay ...
Caspase-12 Fluorometric Assay Kit
KA0733
Species: Ma
Applications: Func
Proteins
Caspase-12 Blocking Peptide
Caspase-12 Blocking Peptide
NBP1-76801PEP
Species: Mu
Applications: AC
Caspase-12 Blocking Peptide
Caspase-12 Blocking Peptide
NBP1-76624PEP
Species: Mu
Applications: AC
Caspase-12 Blocking Peptide
Caspase-12 Blocking Peptide
NBP1-77290PEP
Species: Mu
Applications: AC

Description

Caspases are cysteine proteases that cleave C-terminal aspartic acid residues on their substrate molecules. This gene, CASP12, is most highly related to members of the ICE subfamily of caspases that process inflammatory cytokines. In rodents, the homolog of this gene mediates apoptosis in response to endoplasmic reticulum stress. However, in humans this gene contains a polymorphism for the presence or absence of a premature stop codon. The majority of human individuals have the premature stop codon and produce a truncated non-functional protein. The read-through codon occurs primarily in individuals of African descent and carriers have endotoxin hypo-responsiveness and an increased susceptibility to severe sepsis. (provided by RefSeq)

Bioinformatics

Entrez Human
Human
Mouse
Rat
Uniprot Mouse
Product By Gene ID 100506742
Alternate Names
  • UNQ9415
  • Caspase12
  • Caspase 12 pseudogene 1
  • CASP12P1
  • casp12
  • CASP 12
  • Apoptosis Related Cysteine Protease
  • UNQ9415
  • Caspase12
  • Caspase 12 pseudogene 1
  • CASP12P1
  • casp12
  • CASP 12
  • Apoptosis Related Cysteine Protease

Research Areas for Caspase-12

Find related products by research area and learn more about each of the different research areas below.

Apoptosis
Cancer
Caspases

PTMs for Caspase-12

Learn more about PTMs related to Caspase-12.

Cleavage
Phosphorylation
Ubiquitination
Reduction
Glycosylation
Oxidation

Bioinformatics Tool for Caspase-12

Discover related pathways, diseases and genes to Caspase-12. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
Vizit™, under license from BioVista Inc.

Related Caspase-12 Blog Posts

Check out the latest blog posts on Caspase-12.
Caspase-12 - activator of apoptosis via the ER stress response
Aside from their important role in apoptosis, caspases also play an important role in inflammatory processes. Humans express four inflammatory caspases: Caspase-1, -4, -5, and -12. Caspase-12 is a 48 kDa protein localized to the ER and involved in...    Read more.
Read more Caspase-12 related blogs.