Caspase-12 Products

Description

Caspases are cysteine proteases that cleave C-terminal aspartic acid residues on their substrate molecules. This gene, CASP12, is most highly related to members of the ICE subfamily of caspases that process inflammatory cytokines. In rodents, the homolog of this gene mediates apoptosis in response to endoplasmic reticulum stress. However, in humans this gene contains a polymorphism for the presence or absence of a premature stop codon. The majority of human individuals have the premature stop codon and produce a truncated non-functional protein. The read-through codon occurs primarily in individuals of African descent and carriers have endotoxin hypo-responsiveness and an increased susceptibility to severe sepsis. (provided by RefSeq)

Bioinformatics

Product By Gene ID	100506742
Alternate Names	Apoptosis Related Cysteine Protease CASP 12 CASP12 CASP12P1 Caspase 12 pseudogene 1 Caspase12 Caspase-12 UNQ9415

Research Areas for Caspase-12

Find related products by research area and learn more about each of the different research areas below.

Apoptosis
Cancer
Caspases

Related Caspase-12 Blog Posts

Check out the latest blog posts on Caspase-12.

Caspase-12 - activator of apoptosis via the ER stress response Aside from their important role in apoptosis, caspases also play an important role in inflammatory processes. Humans express four inflammatory caspases: Caspase-1, -4, -5, and -12. Caspase-12 is a 48 kDa protein localized to the ER and involved in ...    Read more.

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