CASK Peptide

Product Discontinued

CASK Peptide Summary

• Immunogen: This protein is not active and should not be used for experiments requiring activity.
• Protein/Peptide Type: Peptide
• Gene: CASK

Applications/Dilutions

• Dilutions:
  • Block/Neutralize
• Application Notes: This peptide is useful as a blocking peptide for PAB2776.
  This product may contain endotoxins and is not suitable for use with live cells.
  
  For further blocking peptide related protocol, click here.

Reactivity Notes

Human

Packaging, Storage & Formulations

• Storage: Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
• Buffer: Lyophilized with 100% acetonitrile. Reconstitute with 100 uL deionized water for a final concentration of 1 mg/mL.
• Preservative: No Preservative

Notes

This product is produced by and distributed for Abnova, a company based in Taiwan.

Alternate Names for CASK Peptide

• calcium/calmodulin-dependent serine protein kinase (MAGUK family)
• calcium/calmodulin-dependent serine protein kinase membrane-associatedguanylate kinase
• Calcium/calmodulin-dependent serine protein kinase
• CAMGUK
• CMG
• EC 2.7.11
• EC 2.7.11.1
• FGS4CAGH39
• FLJ22219
• hCASK
• LIN2FLJ31914
• MICPCH
• peripheral plasma membrane protein CASK
• Protein lin-2 homolog
• TNRC8
• trinucleotide repeat containing 8

Background

Calmodulin sensitive kinase (CASK/mLIN-2) is a ~112-kDa member of the membrane associated quanylate kinase (MAGUK) protein family with multiple protein binding domains. These include an N-terminal calmodulin kinase (CaMKII) domain and C-terminal PDZ, SH3-, and quanylate kinase domains. CASK possesses both tyrosine kinase and serine/threonine kinase activity. In addition, CASK can form a heterotrimeric complex with Mint (X11or mLIN-10) and Veli (mLIN-7) proteins which is predicted to participate in plasma membrane receptor localization. CASK is localized to neuronal synapses and also interacts with syndecan and neurexin. The guanylate kinase domain of CASK has been shown to interact with the T-box transcription factor, Tbr-1, as a coactivator to induce transcription of genes that contain T-elements.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Peptides and proteins are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: CASK