CARD11/CARMA1 Antibody (EPR2557)

Product Discontinued

CARD11/CARMA1 Antibody (EPR2557) Summary

• Immunogen: A synthetic peptide corresponding to residues on the C-terminus in human CARD11 was used as an immunogen.
• Clonality: Monoclonal
• Host: Rabbit
• Gene: CARD11
• Purity: Tissue culture supernatant

Applications/Dilutions

• Dilutions:
  • Western Blot 1:1000 - 10000

Reactivity Notes

Reacts with: Human Does not react with Mouse, Rat

Packaging, Storage & Formulations

• Storage: Store at -20C. Avoid freeze-thaw cycles.
• Buffer: 49% PBS, 0.05% BSA and 50% Glycerol
• Preservative: 0.01% Sodium Azide
• Purity: Tissue culture supernatant

Notes

Produced using Abcam's RabMab® technology. RabMab® technology is covered by the following U.S. Patents, No. 5,675,063 and/or 7,429,487.

Alternate Names for CARD11/CARMA1 Antibody (EPR2557)

• BIMP3
• BIMP3card-maguk protein 1
• CARD11
• CARD-containing MAGUK protein 1
• Carma 1
• CARMA1
• CARMA1bcl10-interacting maguk protein 3
• caspase recruitment domain family, member 11
• caspase recruitment domain-containing protein 11
• MGC133069

Background

CARD11 belongs to the membrane-associated guanylate kinase (MAGUK) family, a class of proteins that functions as molecular scaffolds for the assembly of multiprotein complexes at specialized regions of the plasma membrane. It is also a member of the CARD protein family, which is defined by carrying a characteristic caspase-associated recruitment domain (CARD). CARD11 has a domain structure similar to that of CARD14. The CARD domains of both proteins have been shown to specifically interact with BCL10, a protein known to function as a positive regulator of cell apoptosis and NF-kappaB activation. When expressed in cells, CARD11 activated NF-kappaB and induced the phosphorylation of BCL10 (1).

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: CARD11
• Entrez:
  • 84433(Human)
• Uniprot:
  • Q9BXL7(Human)