Carboxylesterase 2/CES2 Antibody [Alexa Fluor™ Plus 680]

• Clonality: Polyclonal
• Host: Goat
• Conjugate: Alexa Fluor Plus 680

Carboxylesterase 2/CES2 Antibody [Alexa Fluor™ Plus 680] Summary

• Specificity: Detects mouse Carboxylesterase 2/CES2 in direct ELISAs and Western blots. In direct ELISAs, approximately 30% cross-reactivity with recombinant human CES2 is observed and approximately 5% cross-reactivity with recombinant mouse (rm) CES3 and rmCES5 is observed.
• Isotype: IgG
• Clonality: Polyclonal
• Host: Goat

Packaging, Storage & Formulations

• Storage: Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied
• Buffer: Supplied 0.2 mg/mL in a saline solution containing BSA and Sodium Azide.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Carboxylesterase 2/CES2 Antibody [Alexa Fluor™ Plus 680]

• carboxylesterase 2 (intestine, liver)
• Carboxylesterase 2
• carboxylesterase 2EC 3.1.1.1
• CE-2
• CE-2PCE-2
• CES2
• CES2A1
• EC 3.1.1
• EC 3.1.1.84
• hCE-2
• iCE
• intestinal carboxylesterase; liver carboxylesterase-2
• PCE-2

Background

Carboxylesterase 2 is a member of a large family of carboxylesterases that are responsible for the hydrolysis of ester and amide bonds (1, 2). They have broad substrate specificity ranging from small molecule esters such as phenylester to long-chain fatty acid esters and thioesters. Carboxylesterases play a major role as determinants of pharmacokinetic behavior for most therapeutic agents containing an ester, participating in the detoxification of drugs such as cocaine and heroin in serum and liver. They can also detoxify organophosphate and carbamate analogues used in agrochemicals or chemical nerve agents, such as malathion, sarin, tabun, and VX. Carboxylesterases can also perform transesterification, a reaction important for cholesterol homeostasis. Carboxylesterase deficiency may be associated with non-Hodgkin lymphoma or B-cell lymphocytic leukemia. CES2, also known as acylcarnitine hydrolase M1, shares the serine hydrolase fold observed in other esterases (3). CES2 possesses an endoplasmic reticulum retention signal (HREL) at its C-terminus. The expressed rmCES2 lacks this signal, resulting in its secretion.

1. Redinbo, M. R. and P.M. Potter (2005) Drug Discovery Today 10:313.
2. Satoh, T. and M. Hosokawa (2006) Chem.-Biol. Interactions 162:195.
3. Fleming, C. D. et al. (2007) Biochemistry 46:5603.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.