Western Blot: CaMKII beta Antibody [NB120-22131] - Analysis of CAMKIIb in rat brain lysate using NB120-22131 at 1:2000.
Immunocytochemistry/ Immunofluorescence: CaMKII beta Antibody [NB120-22131] - Staining of CAMKIIb using NB120-22131 in rat hippocampal neurons at a dilution of 1:100, note that staining is rather weak.
Western Blot: CaMKII beta Antibody [NB120-22131] - Analysis of CAMKII beta in A) human, B) mouse and C) rat brain lysate using CAMKII beta antibody at 1:2000.
This antibody was developed against a synthetic peptide corresponding to amino acids 499-513 (VRRGSGTPEAEAPRQ) of human CAMKII beta.
Cytoplasmic, widely expressed; expressed in adult and fetal brain. (Expression is lightly lower in fetal brain.)
Human CAMKII beta GenBank no. GENE ID: 816 CAMK2B is a 664 amino acid protein. However, several isoforms of varying amino acid sizes have been described for CAMKII beta. Researchers are encouraged to utilize the sequence information used for immunogen (VRRGSGTPEAEAPRQ) to gain additional information about these isoforms and various molecular weights which may be detected by western blot analysis.
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calcium/calmodulin-dependent protein kinase (CaM kinase) II beta
calcium/calmodulin-dependent protein kinase II beta
calcium/calmodulin-dependent protein kinase type II beta chain
calcium/calmodulin-dependent protein kinase type II subunit beta
CaM kinase II beta subunit
CaM kinase II subunit beta
CaMK-II subunit beta
CaM-kinase II beta chain
proline rich calmodulin-dependent protein kinase
The multifunctional CaMKII beta, or Ca2+/calmodulin-dependent protein kinase II, is a well known effector of calcium- and calmodulin- mediated functions. It is present in many tissues but is most abundant in the brain. CaMKII is composed of four different chains: alpha, beta, gamma, and delta. The different isoforms assemble into homo- or heteromultimeric holoenzymes composed of 8 to 12 subunits. Autophosphorylation plays an important role in the regulation of the kinase activity. CaMKII is required for synaptic plasticity, as in Long Term Potentiation (LTP), a cellular model for learning and memory.
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.